Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nisoldipine
Drug ID BADD_D01570
Description Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
Indications and Usage For the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
Marketing Status Prescription; Discontinued
ATC Code C08CA07
DrugBank ID DB00401
KEGG ID D00618
MeSH ID D015737
PubChem ID 4499
NDC Product Code 0378-2098; 46708-925; 0378-2096; 0378-2223; 70515-503; 0378-2224; 13672-043; 0378-2099; 70515-501; 66993-472; 70515-500; 13672-042; 66993-475; 0378-2222; 49706-1607; 66993-473; 0378-2097; 13672-041
Synonyms Nisoldipine | Bay K 5552
Chemical Information
Molecular Formula C20H24N2O6
CAS Registry Number 63675-72-9
SMILES CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal dreams17.15.02.001; Available
Acne23.02.01.001--Not Available
Amblyopia06.02.01.001--Not Available
Angioedema10.01.05.009; Available
Asthma22.03.01.002; Available
Atrial fibrillation02.03.03.002--
Atrioventricular block first degree02.03.01.004--
Blepharitis23.03.04.012; Available
Blindness17.17.01.003; Available
Blindness unilateral17.17.01.016; Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.001--Not Available
Cellulitis11.02.01.001; Available
Cerebral ischaemia24.04.06.003;
Cerebrovascular accident24.03.05.001;
Chest discomfort22.02.08.001;; Available
Chest pain22.02.08.003;; Available
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