Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine alkaloid
Drug ID BADD_D01565
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status Prescription; OTC; Discontinued
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 942
TTD Drug ID D02BPT
NDC Product Code 0536-1106; 52922-001; 11822-3627; 0220-3657; 60429-444; 63868-734; 11673-194; 37808-739; 37808-753; 0135-0196; 49035-196; 50090-1148; 55741-449; 70000-0113; 28663-009; 28663-010; 11673-424; 37808-682; 37808-707; 0135-0194; 55910-313; 69842-605; 70000-0114; 70677-0032; 21130-269; 37808-658; 37808-948; 43598-445; 49035-782; 59450-003; 59779-445; 60429-445; 63981-124; 63981-190; 66715-9806; 70677-0030; 11673-727; 29485-5270; 29485-5271; 37808-849; 49035-195; 59779-443; 59779-448; 60505-7093; 62011-0349; 68016-288; 0363-0455; 0363-0457; 0536-5894; 11673-196; 11673-971; 37808-900; 43598-446; 43598-448; 66715-9802; 66715-9805; 0363-0451; 0536-1108; 0536-5895; 75877-0002; 81870-001; 59450-001; 62011-0351; 0536-1107; 11673-269; 37808-383; 50090-1697; 60429-443; 63868-735; 68016-290; 69842-828; 70000-0115; 0536-5896; 17205-601; 11673-195; 11673-881; 21130-820; 49348-788; 0009-5400; 0009-5401; 50090-1972; 50090-2860; 60505-7091; 62011-0350; 66715-9801; 50392-101; 55742-003; 61252-3005; 11673-879; 37808-533; 37808-711; 37808-911; 0135-0195; 43598-447; 49035-194; 59450-002; 60505-7092; 66715-9803; 66715-9804; 68016-289; 70677-0031
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bladder transitional cell carcinomaPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformP42338T05031Not Available
Bladder transitional cell carcinomaRAC-alpha serine/threonine-protein kinaseP31749T67619Not Available
Bladder transitional cell carcinomaSerine/threonine-protein kinase mTORP42345T75243Not Available
Cell deathCollagen alpha-1(I) chainP02452Not AvailableNot Available
Colitis ulcerativeInterleukin-8P10145T22658Not Available
Drug tolerance increasedCholine O-acetyltransferaseP28329Not AvailableNot Available
Erectile dysfunctionProstaglandin G/H synthase 2O02768Not AvailableNot Available
Tardive dyskinesiaCytochrome P450 1A2P05177Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Aphthous ulcer07.05.06.002--Not Available
Atrial fibrillation02.03.03.002--
Cough22.02.03.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Headache17.14.01.001--
Hiccups22.02.04.002; 07.01.06.009--
Insomnia19.02.01.002; 17.15.03.002--
Local reaction08.01.03.012--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Palpitations02.01.02.003--
Vomiting07.01.07.003--
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