ADReCS

Pharmaceutical Information

Drug Name	Nicotine
Drug ID	BADD_D01564
Description	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage	For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status	approved
ATC Code	N07BA01
DrugBank ID	DB00184
KEGG ID	D03365
MeSH ID	D009538
PubChem ID	89594
TTD Drug ID	D0T8GD
NDC Product Code	17205-601; 58316-010; 11673-195; 11673-879; 37808-900; 37808-948; 43598-447; 59450-003; 59779-443; 70000-0115; 0536-1107; 70677-0030; 52922-001; 58316-009; 75877-0002; 11822-3627; 11822-4975; 21130-820; 37808-533; 37808-658; 43598-448; 49035-195; 55910-313; 66715-9802; 66715-9805; 66715-9806; 70000-0114; 28663-009; 58316-006; 11673-727; 11673-881; 37808-682; 0135-0196; 37808-711; 37808-739; 49035-196; 53329-192; 59450-002; 60429-443; 60429-445; 62011-0351; 63868-734; 70677-0032; 60429-444; 0363-0455; 0363-0457; 66715-9804; 68016-288; 28663-010; 58316-011; 11822-4973; 37808-753; 43598-446; 0009-5401; 50090-1148; 53329-193; 68016-289; 0536-1108; 58316-008; 29485-5271; 50090-2860; 63981-124; 66715-9803; 68196-194; 0536-1106; 61252-3005; 50090-1697; 59450-001; 63981-190; 70677-0031; 0135-0194; 0135-0195; 49035-782; 49348-788; 50090-2837; 59779-445; 62011-0350; 63868-735; 66715-9801; 68016-290; 69842-828; 50392-101; 55742-003; 11673-971; 11822-4974; 37808-707; 37808-849; 50090-6383; 55741-449; 59779-448; 0363-0451; 62011-0349; 81870-001; 11673-269; 11673-424; 21130-269; 43598-445; 53329-191; 69842-605; 70000-0113; 58316-007; 11673-194; 11673-196; 29485-5270; 37808-383; 37808-911; 49035-194; 0009-5400
UNII	6M3C89ZY6R
Synonyms	Nicotine \| Nicotine Bitartrate \| Nicotine Tartrate

Chemical Information

Molecular Formula	C10H14N2
CAS Registry Number	54-11-5; 22083-74-5
SMILES	CN1CCCC1C2=CN=CC=C2
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Nightmare	19.02.03.003	0.005955%		Not Available
Nonspecific reaction	08.01.03.040	0.004263%		Not Available
Oedema	14.05.06.010; 08.01.07.006	0.002633%		Not Available
Oedema mouth	23.04.01.008; 10.01.05.006; 07.05.04.001	-	-	Not Available
Oedema peripheral	14.05.06.011; 08.01.07.007; 02.05.04.007	-	-
Oesophageal spasm	07.02.04.004	-	-	Not Available
Oligohydramnios	18.05.01.001	0.001567%		Not Available
Oral discomfort	07.05.05.001	0.002758%		Not Available
Oral pain	07.05.05.034	0.001379%
Pain	08.01.08.004	-	-
Pain in jaw	15.02.01.003	0.001692%		Not Available
Pallor	24.03.04.001; 23.03.03.031; 08.01.03.032	-	-	Not Available
Palpitations	02.11.04.012	0.008086%
Pancreatitis acute	07.18.01.002	0.000940%		Not Available
Panic attack	19.06.04.001	0.003385%		Not Available
Paraesthesia	23.03.03.094; 17.02.06.005	-	-
Paralysis	17.01.04.004	-	-	Not Available
Parosmia	22.04.03.007; 17.04.04.002	-	-	Not Available
Periorbital oedema	23.04.01.002; 10.01.05.010; 06.08.03.017	-	-
Peripheral vascular disorder	24.03.01.003	0.000940%		Not Available
Personality disorder	19.05.02.002	-	-	Not Available
Pharyngeal oedema	23.04.01.016; 22.04.05.003; 10.01.05.016	0.002006%		Not Available
Pharyngitis	22.07.03.004; 11.01.13.003; 07.05.07.004	-	-
Photopsia	17.17.01.006; 06.02.06.004	0.000940%
Photosensitivity reaction	23.03.09.003	-	-
Pollakiuria	20.02.02.007	0.000940%
Polyhydramnios	18.05.01.002	0.001254%		Not Available
Postpartum haemorrhage	24.07.03.003; 18.06.01.001	0.000940%		Not Available
Pre-eclampsia	24.08.07.002; 20.01.08.002; 18.02.03.002	0.001567%		Not Available
Premature baby	18.04.02.001	0.005015%		Not Available

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