Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status Prescription; OTC; Discontinued
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 59779-443; 0536-5895; 0536-1108; 62011-0350; 69842-605; 59779-448; 43598-448; 68016-289; 60429-443; 11673-196; 49035-194; 66715-9804; 60505-7092; 49035-196; 0135-0194; 50090-1972; 43598-445; 0009-5400; 59450-001; 70677-0031; 60429-445; 49348-788; 0536-5896; 37808-900; 70677-0030; 0009-5401; 66715-9806; 63981-190; 37808-849; 50090-1148; 66715-9801; 63981-124; 0135-0195; 29485-5270; 70000-0115; 29485-5271; 37808-948; 43598-447; 0220-3657; 60505-7091; 55741-449; 37808-533; 60429-444; 49035-782; 11673-971; 11822-3627; 37808-707; 60505-7093; 37808-383; 50090-1697; 37808-739; 21130-269; 0363-0451; 59779-445; 70000-0113; 62011-0349; 68016-288; 28663-009; 75877-0002; 37808-911; 52922-001; 0135-0196; 11673-879; 17205-601; 70677-0032; 0536-1106; 37808-753; 11673-194; 70000-0114; 50090-2860; 66715-9803; 37808-682; 81870-001; 59450-002; 63868-734; 37808-658; 43598-446; 61252-3005; 11673-727; 0363-0455; 0536-1107; 11673-195; 0536-5894; 49035-195; 28663-010; 11673-881; 55742-003; 21130-820; 63868-735; 37808-711; 59450-003; 66715-9805; 50392-101; 11673-424; 55910-313; 11673-269; 68016-290; 69842-828; 62011-0351; 0363-0457; 66715-9802
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bladder transitional cell carcinomaPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformP42338T05031Not Available
Bladder transitional cell carcinomaRAC-alpha serine/threonine-protein kinaseP31749T67619Not Available
Bladder transitional cell carcinomaSerine/threonine-protein kinase mTORP42345T75243Not Available
Cell deathCollagen alpha-1(I) chainP02452Not AvailableNot Available
Colitis ulcerativeInterleukin-8P10145T2265810453373; 9361176; 9753275
Drug tolerance increasedCholine O-acetyltransferaseP28329Not Available3712280; 1528936; 3772799; 1920127
Erectile dysfunctionProstaglandin G/H synthase 2O02768Not Available25954131
Tardive dyskinesiaCytochrome P450 1A2P05177Not Available10889552; 11496364; 15564895
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Panic attack19.06.04.0010.007655%Not Available
Paraesthesia17.02.06.005--
Peripheral vascular disorder24.03.01.0030.003828%Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.005103%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photopsia17.17.01.006; 06.02.06.0040.003828%
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.0070.003828%
Polyhydramnios18.05.01.0020.005103%Not Available
Postpartum haemorrhage24.07.03.003; 18.06.01.0010.003828%Not Available
Pre-eclampsia24.08.07.002; 20.01.08.002; 18.02.03.0020.005103%Not Available
Premature baby18.04.02.0010.016586%Not Available
Premature delivery18.07.01.0060.008931%
Premature labour18.07.01.0020.007655%Not Available
Premature rupture of membranes18.07.01.0030.003828%Not Available
Premature separation of placenta24.07.03.019; 18.02.01.0040.003828%Not Available
Proteinuria20.02.01.0110.003828%
Pruritus23.03.12.0010.016586%
Psoriasis10.02.01.036; 23.03.14.0020.006379%Not Available
Psychomotor hyperactivity19.11.02.003; 17.01.02.0110.002552%Not Available
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.0020.000666%Not Available
Pulse absent13.14.04.0050.002552%Not Available
Pyelonephritis20.01.09.001; 11.01.14.0020.003828%Not Available
Pyrexia08.05.02.003--
Rash23.03.13.0010.034448%Not Available
Rash erythematous23.03.06.0030.002552%Not Available
Rash generalised23.03.13.0020.006379%Not Available
Rash pustular23.03.10.003; 11.01.12.0020.002552%
Renal failure20.01.03.005--Not Available
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