Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status Prescription; OTC; Discontinued
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 59779-443; 0536-5895; 0536-1108; 62011-0350; 69842-605; 59779-448; 43598-448; 68016-289; 60429-443; 11673-196; 49035-194; 66715-9804; 60505-7092; 49035-196; 0135-0194; 50090-1972; 43598-445; 0009-5400; 59450-001; 70677-0031; 60429-445; 49348-788; 0536-5896; 37808-900; 70677-0030; 0009-5401; 66715-9806; 63981-190; 37808-849; 50090-1148; 66715-9801; 63981-124; 0135-0195; 29485-5270; 70000-0115; 29485-5271; 37808-948; 43598-447; 0220-3657; 60505-7091; 55741-449; 37808-533; 60429-444; 49035-782; 11673-971; 11822-3627; 37808-707; 60505-7093; 37808-383; 50090-1697; 37808-739; 21130-269; 0363-0451; 59779-445; 70000-0113; 62011-0349; 68016-288; 28663-009; 75877-0002; 37808-911; 52922-001; 0135-0196; 11673-879; 17205-601; 70677-0032; 0536-1106; 37808-753; 11673-194; 70000-0114; 50090-2860; 66715-9803; 37808-682; 81870-001; 59450-002; 63868-734; 37808-658; 43598-446; 61252-3005; 11673-727; 0363-0455; 0536-1107; 11673-195; 0536-5894; 49035-195; 28663-010; 11673-881; 55742-003; 21130-820; 63868-735; 37808-711; 59450-003; 66715-9805; 50392-101; 11673-424; 55910-313; 11673-269; 68016-290; 69842-828; 62011-0351; 0363-0457; 66715-9802
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bladder transitional cell carcinomaPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformP42338T05031Not Available
Bladder transitional cell carcinomaRAC-alpha serine/threonine-protein kinaseP31749T67619Not Available
Bladder transitional cell carcinomaSerine/threonine-protein kinase mTORP42345T75243Not Available
Cell deathCollagen alpha-1(I) chainP02452Not AvailableNot Available
Colitis ulcerativeInterleukin-8P10145T2265810453373; 9361176; 9753275
Drug tolerance increasedCholine O-acetyltransferaseP28329Not Available3712280; 1528936; 3772799; 1920127
Erectile dysfunctionProstaglandin G/H synthase 2O02768Not Available25954131
Tardive dyskinesiaCytochrome P450 1A2P05177Not Available10889552; 11496364; 15564895
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mood swings19.04.03.001--Not Available
Mouth ulceration07.05.06.0040.002552%Not Available
Movement disorder17.01.02.0100.002552%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.005--Not Available
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.0070.005325%
Myocardial ischaemia24.04.04.010; 02.02.02.0080.001331%Not Available
Myoclonus17.02.05.0080.000666%Not Available
Nasal congestion22.04.04.001--
Nasal ulcer22.04.03.011--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.0010.058689%
Neck pain15.03.04.0090.005103%
Neoplasm malignant16.16.01.0010.001331%Not Available
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.006379%Not Available
Neutropenia01.02.03.004--Not Available
Night sweats08.01.03.031; 23.02.03.0060.003828%Not Available
Nightmare19.02.03.0030.007655%Not Available
Oedema08.01.07.006; 14.05.06.0100.005103%Not Available
Oedema peripheral14.05.06.011; 02.05.04.007; 08.01.07.007--
Oligohydramnios18.05.01.0010.005103%Not Available
Oral discomfort07.05.05.0010.005103%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pain in jaw15.02.01.0030.005103%Not Available
Pallor23.03.03.031; 08.01.03.032; 24.03.04.001--Not Available
Palpitations02.01.02.0030.021689%
Pancreatitis acute07.18.01.0020.002552%Not Available
The 7th Page    First    Pre   7 8 9 10 11    Next   Last    Total 13 Pages