Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status approved
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 17205-601; 58316-010; 11673-195; 11673-879; 37808-900; 37808-948; 43598-447; 59450-003; 59779-443; 70000-0115; 0536-1107; 70677-0030; 52922-001; 58316-009; 75877-0002; 11822-3627; 11822-4975; 21130-820; 37808-533; 37808-658; 43598-448; 49035-195; 55910-313; 66715-9802; 66715-9805; 66715-9806; 70000-0114; 28663-009; 58316-006; 11673-727; 11673-881; 37808-682; 0135-0196; 37808-711; 37808-739; 49035-196; 53329-192; 59450-002; 60429-443; 60429-445; 62011-0351; 63868-734; 70677-0032; 60429-444; 0363-0455; 0363-0457; 66715-9804; 68016-288; 28663-010; 58316-011; 11822-4973; 37808-753; 43598-446; 0009-5401; 50090-1148; 53329-193; 68016-289; 0536-1108; 58316-008; 29485-5271; 50090-2860; 63981-124; 66715-9803; 68196-194; 0536-1106; 61252-3005; 50090-1697; 59450-001; 63981-190; 70677-0031; 0135-0194; 0135-0195; 49035-782; 49348-788; 50090-2837; 59779-445; 62011-0350; 63868-735; 66715-9801; 68016-290; 69842-828; 50392-101; 55742-003; 11673-971; 11822-4974; 37808-707; 37808-849; 50090-6383; 55741-449; 59779-448; 0363-0451; 62011-0349; 81870-001; 11673-269; 11673-424; 21130-269; 43598-445; 53329-191; 69842-605; 70000-0113; 58316-007; 11673-194; 11673-196; 29485-5270; 37808-383; 37808-911; 49035-194; 0009-5400
UNII 6M3C89ZY6R
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5; 22083-74-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tobacco abuse19.07.06.0210.007021%Not Available
Weight loss poor14.03.02.027--Not Available
Xanthogranuloma16.21.04.005; 01.13.04.005; 15.09.01.0090.000940%Not Available
Non-small cell lung cancer metastatic22.08.01.021; 16.19.01.0090.000627%Not Available
Foetal heart rate disorder18.03.02.014; 02.03.02.0250.000627%Not Available
Pyelocaliectasis20.01.06.0110.000627%Not Available
Neurodevelopmental disorder19.22.02.003; 17.02.10.0310.000627%Not Available
Skin plaque23.03.03.044--Not Available
Foetal hypokinesia18.03.02.0150.000627%Not Available
Helplessness19.01.02.013--Not Available
Infantile apnoea22.11.02.004; 18.04.15.0030.000940%Not Available
Tongue discomfort07.14.02.019--Not Available
Behaviour disorder19.01.01.0050.001379%Not Available
Drug use disorder19.07.06.0120.002194%Not Available
Laryngeal dysplasia22.04.01.0110.001254%Not Available
Neonatal seizure18.04.04.019; 17.12.03.0380.000940%Not Available
Reaction to excipient10.01.01.042--Not Available
Substance use disorder19.07.06.0200.000940%Not Available
Symphysiolysis21.07.04.017; 18.02.02.026; 15.07.02.0110.000940%Not Available
Taste disorder07.14.03.004; 17.02.07.029--Not Available
Therapeutic product effect increased08.06.01.0530.002758%Not Available
Treatment noncompliance12.09.02.006; 08.06.01.0670.021689%Not Available
Twin pregnancy18.08.03.0020.000627%Not Available
Vocal cord cyst22.04.01.017; 16.38.02.0030.000627%Not Available
Paraesthesia mucosal17.02.06.058; 08.01.06.032--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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