Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicotine
Drug ID BADD_D01564
Description Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status Prescription; OTC; Discontinued
ATC Code N07BA01
DrugBank ID DB00184
KEGG ID D03365
MeSH ID D009538
PubChem ID 89594
TTD Drug ID D0T8GD
NDC Product Code 59779-443; 0536-5895; 0536-1108; 62011-0350; 69842-605; 59779-448; 43598-448; 68016-289; 60429-443; 11673-196; 49035-194; 66715-9804; 60505-7092; 49035-196; 0135-0194; 50090-1972; 43598-445; 0009-5400; 59450-001; 70677-0031; 60429-445; 49348-788; 0536-5896; 37808-900; 70677-0030; 0009-5401; 66715-9806; 63981-190; 37808-849; 50090-1148; 66715-9801; 63981-124; 0135-0195; 29485-5270; 70000-0115; 29485-5271; 37808-948; 43598-447; 0220-3657; 60505-7091; 55741-449; 37808-533; 60429-444; 49035-782; 11673-971; 11822-3627; 37808-707; 60505-7093; 37808-383; 50090-1697; 37808-739; 21130-269; 0363-0451; 59779-445; 70000-0113; 62011-0349; 68016-288; 28663-009; 75877-0002; 37808-911; 52922-001; 0135-0196; 11673-879; 17205-601; 70677-0032; 0536-1106; 37808-753; 11673-194; 70000-0114; 50090-2860; 66715-9803; 37808-682; 81870-001; 59450-002; 63868-734; 37808-658; 43598-446; 61252-3005; 11673-727; 0363-0455; 0536-1107; 11673-195; 0536-5894; 49035-195; 28663-010; 11673-881; 55742-003; 21130-820; 63868-735; 37808-711; 59450-003; 66715-9805; 50392-101; 11673-424; 55910-313; 11673-269; 68016-290; 69842-828; 62011-0351; 0363-0457; 66715-9802
Synonyms Nicotine | Nicotine Bitartrate | Nicotine Tartrate
Chemical Information
Molecular Formula C10H14N2
CAS Registry Number 54-11-5
SMILES CN1CCCC1C2=CN=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Bladder transitional cell carcinomaPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformP42338T05031Not Available
Bladder transitional cell carcinomaRAC-alpha serine/threonine-protein kinaseP31749T67619Not Available
Bladder transitional cell carcinomaSerine/threonine-protein kinase mTORP42345T75243Not Available
Cell deathCollagen alpha-1(I) chainP02452Not AvailableNot Available
Colitis ulcerativeInterleukin-8P10145T2265810453373; 9361176; 9753275
Drug tolerance increasedCholine O-acetyltransferaseP28329Not Available3712280; 1528936; 3772799; 1920127
Erectile dysfunctionProstaglandin G/H synthase 2O02768Not Available25954131
Tardive dyskinesiaCytochrome P450 1A2P05177Not Available10889552; 11496364; 15564895
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac disorder02.01.01.003--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.0020.005103%Not Available
Motor dysfunction17.02.10.004--Not Available
Temperature regulation disorder08.05.01.0040.002552%Not Available
Uterine contractions abnormal18.07.02.002; 21.07.03.0030.003828%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Respiratory disorder neonatal22.11.01.002; 18.04.09.0020.005103%Not Available
Ill-defined disorder08.01.03.0490.002552%Not Available
Mitral valve disease02.07.01.0030.002552%
Drug intolerance08.06.01.013--Not Available
Psychotic disorder19.03.01.0020.002552%
Salivary gland disorder07.06.02.0010.002552%Not Available
Congenital musculoskeletal anomaly15.11.06.002; 03.11.06.0020.000666%Not Available
Facial spasm17.04.03.0100.002552%Not Available
Cystitis noninfective20.03.02.001--
Oral herpes11.05.02.005; 07.05.07.002--Not Available
Pharyngeal disorder22.04.05.0070.002552%Not Available
Low birth weight baby18.04.02.0030.017862%Not Available
Type 1 diabetes mellitus14.06.01.010; 05.06.01.010; 10.04.08.0070.003828%Not Available
Oral disorder07.05.01.0050.006379%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.008931%
Tobacco poisoning12.03.01.054--Not Available
Acute kidney injury20.01.03.016--
Hypoxic-ischaemic encephalopathy24.04.06.021; 22.02.02.011; 17.13.02.0060.000666%Not Available
Foetal growth restriction18.03.01.0020.007655%
Foetal heart rate deceleration abnormality18.03.02.012; 02.03.02.0220.002552%Not Available
Deafness congenital04.02.01.013; 03.13.03.0020.002552%Not Available
Enamel anomaly07.09.02.0030.002552%Not Available
Large for dates baby18.04.02.0040.002552%Not Available
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