ADReCS

Pharmaceutical Information

Drug Name	Nicotine
Drug ID	BADD_D01564
Description	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Indications and Usage	For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Marketing Status	approved
ATC Code	N07BA01
DrugBank ID	DB00184
KEGG ID	D03365
MeSH ID	D009538
PubChem ID	89594
TTD Drug ID	D0T8GD
NDC Product Code	17205-601; 58316-010; 11673-195; 11673-879; 37808-900; 37808-948; 43598-447; 59450-003; 59779-443; 70000-0115; 0536-1107; 70677-0030; 52922-001; 58316-009; 75877-0002; 11822-3627; 11822-4975; 21130-820; 37808-533; 37808-658; 43598-448; 49035-195; 55910-313; 66715-9802; 66715-9805; 66715-9806; 70000-0114; 28663-009; 58316-006; 11673-727; 11673-881; 37808-682; 0135-0196; 37808-711; 37808-739; 49035-196; 53329-192; 59450-002; 60429-443; 60429-445; 62011-0351; 63868-734; 70677-0032; 60429-444; 0363-0455; 0363-0457; 66715-9804; 68016-288; 28663-010; 58316-011; 11822-4973; 37808-753; 43598-446; 0009-5401; 50090-1148; 53329-193; 68016-289; 0536-1108; 58316-008; 29485-5271; 50090-2860; 63981-124; 66715-9803; 68196-194; 0536-1106; 61252-3005; 50090-1697; 59450-001; 63981-190; 70677-0031; 0135-0194; 0135-0195; 49035-782; 49348-788; 50090-2837; 59779-445; 62011-0350; 63868-735; 66715-9801; 68016-290; 69842-828; 50392-101; 55742-003; 11673-971; 11822-4974; 37808-707; 37808-849; 50090-6383; 55741-449; 59779-448; 0363-0451; 62011-0349; 81870-001; 11673-269; 11673-424; 21130-269; 43598-445; 53329-191; 69842-605; 70000-0113; 58316-007; 11673-194; 11673-196; 29485-5270; 37808-383; 37808-911; 49035-194; 0009-5400
UNII	6M3C89ZY6R
Synonyms	Nicotine \| Nicotine Bitartrate \| Nicotine Tartrate

Chemical Information

Molecular Formula	C10H14N2
CAS Registry Number	54-11-5; 22083-74-5
SMILES	CN1CCCC1C2=CN=CC=C2
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal discomfort	07.01.06.001	-	-	Not Available
Abdominal pain	07.01.05.002	-	-
Abdominal pain upper	07.01.05.003	-	-
Abnormal dreams	19.02.03.001; 17.15.02.001	0.002194%		Not Available
Abnormal faeces	07.01.03.001	-	-	Not Available
Abortion spontaneous	18.01.04.001	0.001881%		Not Available
Acne	23.02.01.001	-	-	Not Available
Acute respiratory distress syndrome	22.01.03.001; 24.03.02.034; 10.02.01.067	0.000627%
Ageusia	17.02.07.001; 07.14.03.003	0.002131%		Not Available
Aggression	19.05.01.001	0.000940%		Not Available
Agitation	19.06.02.001; 17.02.05.012	-	-
Agitation neonatal	18.04.04.002; 17.02.05.028	0.000627%		Not Available
Amnesia	19.20.01.001; 17.03.02.001	-	-
Anaphylactic reaction	24.06.03.006; 10.01.07.001	0.003260%
Anaphylactic shock	24.06.02.004; 10.01.07.002	0.000940%		Not Available
Aneurysm	24.02.01.001	-	-	Not Available
Anger	19.04.02.001	0.000940%		Not Available
Angina pectoris	24.04.04.002; 02.02.02.002	0.001254%
Angioedema	22.04.02.008; 23.04.01.001; 10.01.05.009	0.002507%		Not Available
Anxiety	19.06.02.002	0.012035%
Apathy	19.04.04.002	-	-	Not Available
Aphasia	19.21.01.001; 17.02.03.001	-	-
Aphonia	17.02.08.009; 22.12.03.001; 19.19.01.002	0.001379%
Aphthous ulcer	07.05.06.002	-	-	Not Available
Application site dermatitis	23.03.04.014; 12.07.01.018; 08.02.01.018	-	-	Not Available
Application site erythema	23.03.06.005; 12.07.01.001; 08.02.01.001	0.016925%		Not Available
Application site irritation	12.07.01.003; 08.02.01.003	0.010218%		Not Available
Application site oedema	12.07.01.020; 08.02.01.020	-	-	Not Available
Application site pain	12.07.01.004; 08.02.01.004	0.003072%		Not Available
Application site pruritus	23.03.12.004; 12.07.01.005; 08.02.01.005	0.017990%		Not Available

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