Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicardipine hydrochloride
Drug ID BADD_D01561
Description A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Indications and Usage Used for the management of patients with chronic stable angina and for the treatment of hypertension.
Marketing Status Prescription; Discontinued
ATC Code C08CA04
DrugBank ID DB00622
KEGG ID D00617
MeSH ID D009529
PubChem ID 41114
TTD Drug ID D0T0KA
NDC Product Code 55150-183; 43898-0124; 0143-9542; 10122-314; 64679-631; 42765-046; 43066-009; 43066-028; 43066-016; 0143-9593; 0378-1430; 62559-205; 0143-9633; 17337-0532; 0378-1020; 43066-026; 51662-1482; 0517-0735; 42806-501; 42806-502; 72572-470; 62559-206; 24658-751; 0143-9634; 43066-021; 51662-1428; 0143-9689; 43898-0103; 10122-325; 10122-313; 76339-117; 47335-882; 24658-750; 43066-024
Synonyms Nicardipine | Cardene | Vasonase | Antagonil | Cardene SR | Dagan | Flusemide | Lecibral | Lincil | Loxen | Lucenfal | Nicardipine Hydrochloride | Hydrochloride, Nicardipine | Nicardipine LA | LA, Nicardipine | Nicardipino Ratiopharm | Perdipine | Ridene | Y-93 | Y 93 | Y93 | Cardene I.V. | Nicardipino Seid
Chemical Information
Molecular Formula C26H30ClN3O6
CAS Registry Number 69441-18-5
SMILES CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angina pectoris24.04.04.002; 02.02.02.002--
Atrioventricular block02.03.01.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Dyspepsia07.01.02.001--
Ear disorder04.03.01.001--Not Available
Electrocardiogram ST segment depression13.14.05.005--Not Available
Electrocardiogram T wave inversion13.14.05.007--Not Available
Headache17.14.01.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypophosphataemia14.04.03.001--
Hypotension24.06.03.002--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pollakiuria20.02.02.007--
Pyrexia08.05.02.003--
Respiratory disorder22.02.07.002--Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Vomiting07.01.07.003--
Deep vein thrombosis24.01.02.003--Not Available
Sinus node dysfunction02.03.03.017--
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