Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nicardipine
Drug ID BADD_D01560
Description A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Indications and Usage Used for the management of patients with chronic stable angina and for the treatment of hypertension.
Marketing Status Prescription; Discontinued
ATC Code C08CA04
DrugBank ID DB00622
KEGG ID D08270
MeSH ID D009529
PubChem ID 4474
TTD Drug ID D0T0KA
NDC Product Code Not Available
Synonyms Nicardipine | Cardene | Vasonase | Antagonil | Cardene SR | Dagan | Flusemide | Lecibral | Lincil | Loxen | Lucenfal | Nicardipine Hydrochloride | Hydrochloride, Nicardipine | Nicardipine LA | LA, Nicardipine | Nicardipino Ratiopharm | Perdipine | Ridene | Y-93 | Y 93 | Y93 | Cardene I.V. | Nicardipino Seid
Chemical Information
Molecular Formula C26H29N3O6
CAS Registry Number 55985-32-5
SMILES CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oxygen saturation decreased13.02.01.004--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Pericardial haemorrhage02.06.01.003; 24.07.01.013--Not Available
Pericarditis02.06.02.001--
Peripheral vascular disorder24.03.01.003--Not Available
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Respiratory disorder22.02.07.002--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Shock24.06.02.002--Not Available
Sinus arrhythmia02.03.03.008--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Somnolence19.02.05.003; 17.02.04.006--
Supraventricular tachycardia02.03.03.012--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Tremor17.01.06.002--
Ventricular extrasystoles02.03.04.007--Not Available
Ventricular tachycardia02.03.04.010--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
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