Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nepafenac
Drug ID BADD_D01555
Description Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Indications and Usage For the treatment of pain and inflammation associated with cataract surgery.
Marketing Status Prescription
ATC Code S01BC10
DrugBank ID DB06802
KEGG ID D05143
MeSH ID C414203
PubChem ID 151075
TTD Drug ID D02IHW
NDC Product Code 69988-0005; 0078-0743; 53296-0099; 64181-0019; 42571-353; 73309-311; 0065-0002; 58567-104
Synonyms nepafenac | 2-amino-3-benzoylbenzeneacetamide | Nevanac
Chemical Information
Molecular Formula C15H14N2O2
CAS Registry Number 78281-72-8
SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Polymenorrhoea21.01.03.003--Not Available
Pregnancy18.08.02.004--Not Available
Pruritus23.03.12.001--
Punctate keratitis06.04.02.0030.002022%Not Available
Retinal haemorrhage06.10.01.001; 24.07.05.0030.001348%Not Available
Rheumatoid arthritis10.04.06.001; 15.01.03.001--Not Available
Scab23.03.03.004--Not Available
Scleritis10.02.01.025; 06.04.07.0020.001348%Not Available
Sinusitis11.01.13.005; 22.07.03.007--
Skin disorder23.03.03.007--Not Available
Teratogenicity12.03.01.032; 03.02.01.004--Not Available
Tinnitus17.04.07.004; 04.04.01.0020.002022%
Urticaria10.01.06.001; 23.04.02.0010.002022%
Vision blurred17.17.01.010; 06.02.06.0070.007413%
Visual acuity reduced06.02.03.001; 17.17.01.0110.007413%
Visual impairment06.02.06.0080.006739%Not Available
Vitreous detachment12.01.04.005; 06.09.01.002--Not Available
Vomiting07.01.07.003--
Balance disorder17.02.02.0070.001348%Not Available
Foreign body sensation in eyes06.01.01.0060.004043%Not Available
Conjunctival hyperaemia06.04.01.0040.001348%Not Available
Sticky skin23.03.03.019--Not Available
Eyelid margin crusting06.04.04.005; 23.03.03.0290.002022%Not Available
Eye pruritus06.04.05.0060.002022%Not Available
Ocular discomfort06.08.03.0080.001348%Not Available
Corneal thinning06.06.03.009--Not Available
Cystoid macular oedema12.02.02.005; 06.04.06.0100.013477%Not Available
Angiopathy24.03.02.007--Not Available
Eyelid disorder23.03.03.028; 06.08.03.010--Not Available
Ocular toxicity06.11.01.006; 12.03.01.0310.002022%Not Available
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