Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nefazodone hydrochloride
Drug ID BADD_D01547
Description Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Indications and Usage For the treatment of depression.
Marketing Status approved; withdrawn
ATC Code N06AX06
DrugBank ID DB01149
KEGG ID D00819
MeSH ID C051752
PubChem ID 54911
TTD Drug ID D0X7DE
NDC Product Code 0093-1025; 0093-1026; 63629-7046; 63415-0015; 0093-1024; 0093-7113; 0093-7178
UNII 27X63J94GR
Synonyms nefazodone | Serzone | Dutonin | Nefadar | nefazodone hydrochloride | Lin-Nefazodone | Menfazona | Rulivan | Apo-Nefazodone
Chemical Information
Molecular Formula C25H33Cl2N5O2
CAS Registry Number 82752-99-6
SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Rhabdomyolysis15.05.05.002--
Salivary hypersecretion07.06.01.009--Not Available
Seizure17.12.03.001--
Serotonin syndrome12.03.01.041; 17.05.02.004; 15.05.04.016--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Stomatitis07.05.06.005--
Suicide attempt19.12.01.004--
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Tachycardia02.03.02.007--Not Available
Tendinous contracture15.07.01.001--Not Available
Tenosynovitis15.07.01.004--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tooth abscess07.09.01.003; 11.01.04.003--Not Available
Tremor17.01.06.002--
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary retention20.02.02.011--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Uterine haemorrhage21.07.01.005; 24.07.03.004--
Uterine leiomyoma21.07.02.004; 16.04.02.001--Not Available
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vaginal infection21.14.02.002; 11.01.10.002--
Varicose vein24.10.04.001--Not Available
Vasodilatation24.03.02.003; 23.06.05.006--Not Available
Ventricular extrasystoles02.03.04.007--Not Available
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