Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nefazodone
Drug ID BADD_D01546
Description Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Indications and Usage For the treatment of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AX06
DrugBank ID DB01149
KEGG ID D08257
MeSH ID C051752
PubChem ID 4449
TTD Drug ID D0X7DE
NDC Product Code Not Available
Synonyms nefazodone | Serzone | Dutonin | Nefadar | nefazodone hydrochloride | Lin-Nefazodone | Menfazona | Rulivan | Apo-Nefazodone
Chemical Information
Molecular Formula C25H32ClN5O2
CAS Registry Number 83366-66-9
SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityCytochrome P450 3A4P08684T3784811872324; 9616194; 10445380
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ventricular extrasystoles02.03.04.007--Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred17.17.01.010; 06.02.06.007--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Yawning22.02.05.017--Not Available
Drug tolerance08.06.01.003--Not Available
Musculoskeletal stiffness15.03.01.005--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Haemorrhage24.07.01.002--Not Available
Nuchal rigidity17.05.02.006; 15.05.04.005--Not Available
Muscle relaxant therapy25.16.01.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Urine output increased13.13.03.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction19.08.04.001; 21.03.01.007--
Ill-defined disorder08.01.03.049--Not Available
Cystitis noninfective20.03.02.001--
Candida infection11.03.03.021--
Depersonalisation/derealisation disorder19.14.01.004--Not Available
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