Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nefazodone
Drug ID BADD_D01546
Description Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
Indications and Usage For the treatment of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AX06
DrugBank ID DB01149
KEGG ID D08257
MeSH ID C051752
PubChem ID 4449
TTD Drug ID D0X7DE
NDC Product Code Not Available
Synonyms nefazodone | Serzone | Dutonin | Nefadar | nefazodone hydrochloride | Lin-Nefazodone | Menfazona | Rulivan | Apo-Nefazodone
Chemical Information
Molecular Formula C25H32ClN5O2
CAS Registry Number 83366-66-9
SMILES CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityCytochrome P450 3A4P08684T3784811872324; 9616194; 10445380
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breath odour07.01.06.002--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bursitis15.04.01.001--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Colitis07.08.01.001--
Colitis ulcerative10.02.01.004; 07.08.01.005--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Cough22.02.03.001--
Cystitis20.03.02.002; 11.01.14.001--
Deafness04.02.01.001--Not Available
Dehydration14.05.05.001--
Dependence19.07.02.003--Not Available
Derealisation19.10.02.001--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug dependence19.07.02.009--Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
The 2th Page    First    Pre   2 3 4 5 6    Next   Last    Total 8 Pages