Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Naltrexone hydrochloride
Drug ID BADD_D01528
Description Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Indications and Usage Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
Marketing Status Prescription; Discontinued
ATC Code N07BB04
DrugBank ID DB00704
KEGG ID D02095
MeSH ID D009271
PubChem ID 5485201
TTD Drug ID D0PG8O
NDC Product Code 0406-1170; 68094-853; 50090-3076; 49452-4834; 65724-0055; 17205-108; 16729-081; 50090-4925; 12707-038; 63629-1047; 51927-0157; 0904-7036; 68981-037; 51552-0737; 79572-023; 69641-0001; 63629-1046; 50396-6008; 70312-0887; 38779-0887; 58175-0632; 50090-3929; 70518-1146; 17205-103; 71335-2062; 52465-103; 71335-1480; 0395-8083; 51927-0087; 47335-326; 62756-911; 60870-0395; 63275-9901; 51927-0097; 62135-242; 68084-291; 0406-1479; 49452-4835; 71335-0014; 51224-206; 42291-632; 51927-0193; 50090-2866
Synonyms Naltrexone | Antaxone | Trexan | EN-1639A | EN 1639A | EN1639A | ReVia | Nemexin | Nalorex | Naltrexone Hydrochloride | Celupan
Chemical Information
Molecular Formula C20H24ClNO4
CAS Registry Number 16676-29-2
SMILES C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Blood bilirubin increased13.03.01.008--
Blood pressure abnormal13.14.03.001--Not Available
Blood pressure increased13.14.03.005--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Chills15.05.03.016; 08.01.09.001--
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dyspnoea02.01.03.002; 22.02.01.004--
Dysuria20.02.02.002--
Ejaculation delayed21.03.01.001--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Euphoric mood19.04.02.006--
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