Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nalbuphine hydrochloride
Drug ID BADD_D01520
Description A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Indications and Usage For the relief of moderate to severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AF02
DrugBank ID DB00844
KEGG ID D00843
MeSH ID D009266
PubChem ID 5360733
TTD Drug ID D06ZXH
NDC Product Code 0409-1463; 50396-0201; 0409-1465; 52584-464; 0404-9918; 0404-9917; 0409-1467; 52584-083; 0404-9919; 0406-3310; 71872-7114; 0409-1464; 52465-106; 52584-463; 62991-1546; 49452-4800; 51927-2140; 0406-3360
Synonyms Nalbuphine | Nalbuphine Hydrochloride | Nalbuphine Serb | EN-2234A | EN 2234A | EN2234A | Nubain
Chemical Information
Molecular Formula C21H28ClNO4
CAS Registry Number 23277-43-2
SMILES C1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac arrest02.03.04.001--
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005--Not Available
Death08.04.01.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Derealisation19.10.02.001--Not Available
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 02.01.02.004; 17.02.05.003--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.006--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.009--Not Available
Flushing08.01.03.025; 24.03.01.002; 23.06.05.003--
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