Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafcillin
Drug ID BADD_D01515
Description A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Indications and Usage Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Marketing Status Prescription; Discontinued
ATC Code J01CF06
DrugBank ID DB00607
KEGG ID D08242
MeSH ID D009254
PubChem ID 8982
TTD Drug ID D0A0JH
NDC Product Code 44567-221; 44567-223; 0409-3713; 0781-3126; 0781-9124; 44567-222; 0338-1017; 0338-1019; 0409-3714; 0409-3715; 0781-3124; 0781-9125; 0781-9126; 63323-330; 0781-3125
Synonyms Nafcillin | Naphthamidopenicillin | Nafcil | Nafcillin Sodium | Sodium, Nafcillin | Nafcillin, Monosodium Salt, Anhydrous | Sodium Nafcillin | Nafcillin, Sodium
Chemical Information
Molecular Formula C21H22N2O5S
CAS Registry Number 147-52-4
SMILES CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000213%
Abdominal pain07.01.05.0020.000532%
Agranulocytosis01.02.03.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000319%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.0060.000213%
Blood bilirubin increased13.03.01.0080.000213%
Blood creatinine increased13.13.01.0040.000532%
Blood urea increased13.13.01.0060.000213%Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Cholestasis09.01.01.0010.000319%Not Available
Chromaturia20.02.01.0020.000213%
Circulatory collapse24.06.02.001--Not Available
Confusional state17.02.03.005; 19.13.01.0010.000213%
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.0010.000745%
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug hypersensitivity10.01.01.001--Not Available
Eosinophilia01.02.04.0010.000319%
Extravasation08.01.03.008--Not Available
Faeces discoloured07.01.03.0020.000213%Not Available
Febrile neutropenia08.05.02.004; 01.02.03.0020.000426%
Feeling abnormal08.01.09.014--Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.0020.000213%
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