Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Muromonab-cd3
Drug ID BADD_D01506
Description Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type 2a (IgG2a).
Indications and Usage For treatment of organ transplant recipients, prevention of organ rejection
Marketing Status Not Available
ATC Code L04AA02
DrugBank ID DB00075
KEGG ID D05092
MeSH ID D016853
PubChem ID Not Available
TTD Drug ID D05GVQ
NDC Product Code Not Available
Synonyms Muromonab-CD3 | Muromonab CD3 | OKT3 | Monoclonal Antibody OKT3 | Orthoclone OKT3
Chemical Information
Molecular Formula Not Available
CAS Registry Number 140608-64-6
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory tract congestion22.02.07.003--Not Available
Musculoskeletal stiffness15.03.01.005--Not Available
Vascular occlusion24.04.02.015--Not Available
Cytomegalovirus syndrome11.05.01.005--Not Available
Cognitive disorder19.21.02.001; 17.03.03.003--
Staphylococcal infection11.02.05.002--Not Available
Vasodilation procedure25.03.01.001--Not Available
Adenovirus infection11.05.09.003--Not Available
Bacterial infection11.02.01.005--Not Available
Central nervous system infection17.06.09.001; 11.01.03.004--Not Available
Eyelid disorder23.03.03.028; 06.08.03.010--Not Available
Legionella infection11.02.16.001--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Serratia infection11.02.25.001--Not Available
Cytomegalovirus test13.08.03.004--Not Available
Neoplasm recurrence16.16.02.004--Not Available
Obstructive airways disorder22.03.01.011--Not Available
Cranial nerve paralysis17.04.01.002--Not Available
Psychotic disorder19.03.01.002--
Urinary sediment abnormal13.13.02.007--Not Available
Renal impairment20.01.03.010--Not Available
Brain stem thrombosis17.08.01.034; 24.01.04.011--Not Available
Breath sounds abnormal13.15.01.008--Not Available
Treatment failure08.06.01.017--Not Available
Renal cell carcinoma20.01.04.003; 16.08.02.002--Not Available
Hepatitis B virus test13.08.03.009--Not Available
Hepatitis C virus test13.08.03.011--Not Available
Simplex virus test positive13.08.03.013--Not Available
Pneumocystis jirovecii infection11.03.07.004--Not Available
Delayed graft function12.02.09.015--Not Available
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