Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Morphine
Drug ID BADD_D01498
Description Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.[A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.[L12114]
Indications and Usage For the relief and treatment of severe pain.
Marketing Status Prescription; Discontinued
ATC Code N02AA01
DrugBank ID DB00295
KEGG ID D08233
MeSH ID D009020
PubChem ID 5288826
NDC Product Code 42799-217
Synonyms Morphine | Morphia | Morphine Chloride | Chloride, Morphine | Morphine Sulfate | Sulfate, Morphine | SDZ 202-250 | SDZ 202 250 | SDZ 202250 | SDZ202-250 | SDZ202 250 | SDZ202250 | Morphine Sulfate (2:1), Pentahydrate | MS Contin | Contin, MS | Oramorph SR | Duramorph | Morphine Sulfate (2:1), Anhydrous
Chemical Information
Molecular Formula C17H19NO3
CAS Registry Number 57-27-2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cardiac arrhythmiasMu-type opioid receptorP35372T4776825806604
Cardiac arrhythmiasMu-type opioid receptorP35372T477688383026; 1528399; 1654493; 8490741; 1279757; 7521466
HyperpathiaTranscription factor JunP05412T6908525806604
HyperpathiaMu-type opioid receptorP35372T4776825806604
HyperpathiaMitogen-activated protein kinase 8P45983T4009725806604
HyperpathiaProtein kinase C alpha typeP17252T1280825806604
HyperpathiaMu-type opioid receptorP35372T477688383026; 1528399; 1654493; 8490741; 1279757; 7521466
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sopor17.02.04.021; Available
Communication disorder19.19.01.0080.000703%Not Available
Escherichia infection11.02.10.0040.000469%Not Available
Foetal heart rate disorder18.03.02.014; Available
Heart injury12.01.11.003; Available
Toxicologic test abnormal13.17.02.0140.000244%Not Available
Spinal cord oedema17.10.01.0190.000469%Not Available
Opiates positive13.17.02.0130.000306%Not Available
Pruritus allergic10.01.03.046; Available
Accidental death12.01.08.040; Available
Stress cardiomyopathy24.04.04.026; Available
Fear of death19.06.03.0060.000469%Not Available
Quality of life decreased13.18.01.013--Not Available
Aortic intramural haematoma24.02.03.0040.000122%Not Available
Acute lung injury22.01.03.0100.000367%Not Available
Coma scale abnormal13.07.03.0120.000469%Not Available
Foetal non-stress test abnormal13.21.01.0080.000469%Not Available
Helplessness19.01.02.0130.000469%Not Available
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