Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Morphine
Drug ID BADD_D01498
Description Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.[A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine], and [oxycodone]. Morphine was granted FDA approval in 1941.[L12114]
Indications and Usage Morphine is used for the management of chronic, moderate to severe pain.[A176050] Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.[L5728]
Marketing Status approved; investigational
ATC Code N02AA01
DrugBank ID DB00295
KEGG ID D08233
MeSH ID D009020
PubChem ID 5288826
TTD Drug ID D0WE3O
NDC Product Code 42799-217
UNII 76I7G6D29C
Synonyms Morphine | Morphia | Morphine Chloride | Chloride, Morphine | Morphine Sulfate | Sulfate, Morphine | SDZ 202-250 | SDZ 202 250 | SDZ 202250 | SDZ202-250 | SDZ202 250 | SDZ202250 | Morphine Sulfate (2:1), Pentahydrate | MS Contin | Contin, MS | Oramorph SR | Duramorph | Morphine Sulfate (2:1), Anhydrous
Chemical Information
Molecular Formula C17H19NO3
CAS Registry Number 57-27-2
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Disorganised speech19.19.02.005; 17.02.08.0170.000167%Not Available
Substance dependence19.07.06.0190.000111%Not Available
Helplessness19.01.02.0130.000167%Not Available
Infantile apnoea22.11.02.004; 18.04.15.0030.000557%Not Available
Selective eating disorder19.09.01.012; 14.03.02.0240.000111%Not Available
Catheter site granuloma23.03.15.010; 12.07.02.019; 08.02.02.0190.000111%Not Available
Drug use disorder19.07.06.0120.000278%Not Available
Duodenal obstruction07.13.06.0020.000111%
Endocrinopathy diencephalic05.09.01.0040.000111%Not Available
Implant site discharge12.07.02.037; 08.02.02.0370.000167%Not Available
Inadequate analgesia08.06.01.040; 12.02.20.0060.001181%Not Available
Infusion site granuloma12.07.05.029; 23.03.15.013; 08.02.05.0290.000356%Not Available
Infusion site mass12.07.05.032; 08.02.05.0320.000111%Not Available
Intestinal pseudo-obstruction07.02.02.0200.001192%Not Available
Myocardial injury02.04.02.0460.000111%Not Available
Narcotic bowel syndrome07.02.05.0060.000334%Not Available
Neonatal multi-organ failure18.04.01.025; 08.01.03.0950.000111%Not Available
Neonatal oversedation17.02.04.013; 18.04.01.0080.000223%Not Available
Neonatal respiratory distress22.11.02.015; 18.04.10.0040.000334%Not Available
Non-24-hour sleep-wake disorder19.02.06.006; 17.15.06.0060.000111%Not Available
Obstructive sleep apnoea syndrome22.02.01.038; 19.02.05.012; 17.15.05.003--Not Available
Pharyngeal swelling22.04.05.0280.000468%Not Available
Post stroke epilepsy17.12.03.039; 24.03.05.0170.000111%Not Available
Reaction to excipient10.01.01.0420.000412%Not Available
Sleep disorder due to a general medical condition19.02.04.003--Not Available
Suicide threat19.12.01.008--Not Available
Suspected suicide19.12.01.009; 08.04.01.0170.000167%Not Available
Taste disorder17.02.07.029; 07.14.03.004--Not Available
Therapeutic product effect prolonged08.06.01.0540.000111%Not Available
Therapeutic response changed08.06.01.059--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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