Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mitoxantrone hydrochloride
Drug ID BADD_D01481
Description An anthracenedione-derived antineoplastic agent.
Indications and Usage For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
Marketing Status Prescription; Discontinued
ATC Code L01DB07
DrugBank ID DB01204
KEGG ID D02166
MeSH ID D008942
PubChem ID 51082
TTD Drug ID D0R3JB
NDC Product Code 63323-132; 58598-0005
Synonyms Mitoxantrone | Mitozantrone | DHAQ | NSC-279836 | NSC 279836 | NSC279836 | NSC-287836 | NSC 287836 | NSC287836 | NSC-299195 | NSC 299195 | NSC299195 | NSC-301739 | NSC 301739 | NSC301739 | NSC-301739D | NSC 301739D | NSC301739D | Mitroxone | Pralifan | CL-232325 | CL 232325 | CL232325 | Mitoxantrone Acetate | Acetate, Mitoxantrone | Mitoxantrone Hydrochloride | Hydrochloride, Mitoxantrone | Novantrone | Ralenova | Novantron | Onkotrone
Chemical Information
Molecular Formula C22H30Cl2N4O6
CAS Registry Number 70476-82-3
SMILES C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisG1/S-specific cyclin-D1P24385T12355Not Available
ApoptosisTranscription factor JunP05412T69085Not Available
Cytogenetic investigationsDNA topoisomerase 1P11387T09826Not Available
Toxicity to various agentsEpoxide hydrolase 1P07099Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Acute myeloid leukaemia16.01.05.001; 01.10.05.001--Not Available
Affective disorder19.04.04.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood creatinine abnormal13.13.01.002--Not Available
Blood glucose increased13.02.02.002--Not Available
Blood potassium decreased13.11.01.010--Not Available
Blood urea abnormal13.13.01.005--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Catheterisation cardiac abnormal13.14.07.001--Not Available
Chest pain08.01.08.002; 22.02.08.003; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Chromosome banding abnormal13.22.02.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
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