| Drug Name |
Miconazole nitrate |
| Drug ID |
BADD_D01458 |
| Description |
Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well.[A203636] It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027, L14033, L14396] Miconazole is thought to act primarily through the inhibition of fungal CYP450 14α-lanosterol demethylase activity.[A203636, A203639]
Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.[A214523, L14021] It is currently available as a variety of prescription and over the counter products. Despite having been in clinical use for an extended period, resistance to miconazole among susceptible organisms is relatively low.[A203636] |
| Indications and Usage |
For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor. |
| Marketing Status |
Prescription; Discontinued; OTC |
| ATC Code |
A01AB09; A07AC01; D01AC02; G01AF04; J02AB01; S02AA13 |
| DrugBank ID |
DB01110
|
| KEGG ID |
D00882
|
| MeSH ID |
D008825
|
| PubChem ID |
68553
|
| TTD Drug ID |
D00AXJ
|
| NDC Product Code |
50090-2231; 50066-199; 79503-106; 60524-001; 17337-0530; 68016-073; 41520-616; 65197-103; 42669-071; 72189-345; 42213-398; 70518-2338; 55319-081; 51927-1154; 11673-982; 37808-242; 70000-0040; 23667-817; 23667-808; 0363-0730; 69842-988; 59726-988; 11701-045; 66267-960; 11523-0544; 0363-0199; 23667-812; 11523-1272; 49706-5971; 69842-950; 72288-070; 43689-0025; 63736-026; 63187-885; 50923-1213; 41520-825; 11014-0358; 68754-201; 51672-2070; 0113-0916; 51672-2001; 49035-199; 56062-081; 68599-0207; 11523-4140; 23667-804; 55301-211; 21130-040; 44577-205; 53329-169; 51927-0099; 11509-0081; 37808-199; 0363-0081; 68016-291; 49781-064; 52000-021; 50066-277; 0472-0730; 52935-0009; 11014-0343; 50090-5674; 0536-1134; 41250-982; 11523-4327; 63868-198; 49348-833; 53329-162; 49035-730; 59088-244; 38779-0038; 0713-0252; 30142-081; 70000-0009; 68599-0206; 36800-199; 0113-0214; 37205-589; 49348-689; 11701-067; 49035-737; 12258-242; 51316-005; 72071-101; 68016-731; 52000-061; 68071-2657; 68754-200; 12578-488; 24385-590; 49348-355; 0904-5415; 50066-070; 69396-014; 63736-013; 49348-530; 21130-737; 72288-825; 72654-001; 11014-0045; 36800-081; 0363-0637; 11673-199; 68071-2419; 63347-502; 41520-222; 72288-199; 68016-070; 59779-773; 11086-040; 0316-0231; 21130-121; 0113-0081; 61269-730; 63736-023; 11509-0825; 11523-0919; 62654-147; 42669-072; 55315-737; 86014-205; 63736-010; 0363-1497; 68981-035; 0363-0557; 59208-001; 30142-737; 55545-0400; 23667-819; 59726-989; 0113-9001; 21130-341; 68788-7519; 30142-982; 50090-4356; 70000-0025; 36800-782; 62172-202; 0904-7734; 61269-736; 0363-0737; 29784-145; 0713-0197; 49035-345; 69256-825; 59779-737; 61269-735; 49035-731; 0472-1738; 58980-818; 51672-2035; 59779-839; 0472-0735; 51927-0100; 0113-0825; 63736-017; 0113-7070; 73921-012; 70518-3202; 25119-0824; 37808-825; 37808-928; 0316-0232; 0316-0225; 55315-815; 51552-0122; 50090-2718; 46063-552; 11673-737; 41520-916; 71358-077; 41520-154; 43285-0288; 49035-347; 68788-7374; 63736-019; 21130-102; 41250-199; 51824-078; 49452-4775; 49706-5977; 0363-2070; 11822-0199; 69256-081; 12258-241; 21130-825; 55301-916; 69070-304; 41250-081; 30142-825; 71730-070; 59088-478; 11822-0800; 37205-583; 0363-5201; 24385-606; 69740-328; 63347-810; 69740-329; 0363-5203; 0113-7825; 16864-040; 36800-070; 59088-442; 11701-038; 17518-857; 49706-5972; 11822-1104; 11673-391; 50090-5607; 30142-199; 55910-698; 63736-025; 53329-171; 11673-825; 53329-080; 53329-774; 11822-7310; 0113-7199; 59779-199; 68788-7917; 11673-049; 41250-825; 63347-503; 36800-825; 49348-872; 68788-8107; 49035-341; 43553-0003; 21130-982; 63736-015; 41250-497; 72288-497; 41163-825; 0884-0293; 62991-1104; 73736-115; 55910-081; 24909-202; 11014-0058; 41163-081; 53329-079; 46122-577; 49348-645; 63736-532 |
| Synonyms |
Miconazole | R-14,889 | R 14,889 | R14,889 | Miconazole Nitrate | Nitrate, Miconazole | Miconasil Nitrate | Nitrate, Miconasil | Monistat | Brentan | Dactarin |
