Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metyrosine
Drug ID BADD_D01451
Description An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed)
Indications and Usage For use in the treatment of patients with pheochromocytoma, for preoperative preparation of patients for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignant pheochromocytoma.
Marketing Status Prescription
ATC Code C02KB01
DrugBank ID DB00765
KEGG ID D00762
MeSH ID D019805
PubChem ID 441350
TTD Drug ID D0B3QM
NDC Product Code 73223-007; 25010-305; 69238-1621; 68682-310; 67763-129; 68022-7056; 71554-026; 69575-4022
Synonyms alpha-Methyltyrosine | alpha Methyltyrosine | alpha-Methyl-para-tyrosine | alpha Methyl para tyrosine | alpha-MPT | alpha MPT | alpha-Methyl-p-tyrosine | alpha Methyl p tyrosine | Metyrosine | alpha-Methyltyrosine, (L)-Isomer | Metirosine | Racemetirosine | alpha-Methyltyrosine, (D,L)-Isomer | alpha-Methyltyrosine, (+,-)-Isomer | DL-Tyrosine, alpha-methyl- | alpha-methyl- DL-Tyrosine | alpha-Methyltyrosine Hydrochloride | Hydrochloride, alpha-Methyltyrosine | alpha Methyltyrosine Hydrochloride | Demser
Chemical Information
Molecular Formula C10H13NO3
CAS Registry Number 672-87-7
SMILES CC(CC1=CC=C(C=C1)O)(C(=O)O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Parkinsonism17.01.05.003--Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.016--Not Available
Salivary hypersecretion07.06.01.009--Not Available
Sedation17.02.04.005--Not Available
Speech disorder17.02.08.003; 22.02.05.034; 19.19.02.002--Not Available
Swelling08.01.03.015--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Tremor17.01.06.002--
Trismus17.01.03.004; 15.05.04.004--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Hypervigilance19.01.02.006--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Blood disorder01.05.01.004--Not Available
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