Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoprolol tartrate
Drug ID BADD_D01447
Description Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
Indications and Usage For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Marketing Status Discontinued; Prescription
ATC Code C07AB02
DrugBank ID DB00264
KEGG ID D00601
MeSH ID D008790
PubChem ID 441308
TTD Drug ID D0I2MK
NDC Product Code 72888-101; 52932-0743; 68071-4755; 68645-191; 30698-458; 42708-041; 51407-109; 12634-771; 63187-609; 62584-266; 70518-2193; 52817-359; 71872-7124; 71610-186; 71335-1142; 52817-358; 57664-166; 67296-1667; 51079-255; 71335-0241; 71610-565; 50090-2207; 72888-023; 0904-6342; 52817-360; 70860-300; 57664-477; 58118-0361; 70518-1354; 57451-1163; 0615-8017; 71610-080; 68071-4771; 0615-8016; 43063-938; 63187-103; 57664-167; 61919-415; 72888-004; 70518-1979; 71610-548; 71610-137; 51662-1365; 71610-559; 50090-0488; 65862-064; 67544-387; 58118-1062; 57664-506; 60760-243; 63415-0022; 51927-2697; 68071-4309; 62756-101; 68071-1795; 55289-382; 72888-005; 61919-052; 0409-1778; 0378-0018; 71872-7155; 63187-252; 63187-174; 53002-1005; 68071-4759; 68788-7832; 71610-147; 43353-944; 71610-184; 30698-459; 71335-0192; 63323-660; 68071-4958; 72640-016; 42708-147; 43353-942; 71335-1600; 60760-426; 68071-5236; 57237-102; 50090-4966; 68071-4269; 43353-943; 63629-1462; 71872-7283; 55154-4451; 72611-740; 52343-061; 51552-0915; 50090-2260; 70934-736; 50090-0489; 68071-4014; 35356-782; 70518-3293; 63187-314; 67296-1424; 71872-7226; 65862-063; 62584-267; 53808-1117; 70518-2024; 57237-101; 71610-517; 50090-5060; 38779-0578; 70518-1872; 52817-362; 52817-361; 0904-6341; 70882-133; 71610-556; 68071-4261; 70934-105; 0904-7118; 68071-1794; 62584-265; 76420-054; 68071-4769; 0143-9873; 68645-190; 49452-4718; 50090-1974; 70934-186; 55154-4745; 51655-271; 55700-646; 68071-4747; 68071-4867; 51079-801; 68788-7338; 68071-3337; 57237-100; 68071-4084; 70518-2615; 71872-7225; 49999-575; 51407-110; 36000-033; 72266-122; 68071-1288; 42708-110; 55154-2126; 55154-5512; 53002-1026; 71335-1324; 68071-4356; 71335-0743; 0904-6340; 55154-4752; 60760-553; 50090-5070; 70882-132; 68071-4957; 0378-4593; 0378-0047; 52932-0710; 0615-8322; 0378-4594; 55154-4790; 52343-059; 52343-060; 50090-2149; 60760-295; 72888-006; 68083-131; 42419-009; 71610-158; 70518-0381; 65862-062; 68788-7548; 71335-0607; 68071-4307; 71335-1146; 63629-8101; 51662-1478; 63187-532; 0378-0032; 71335-1157; 62991-2897; 71610-443; 43063-927; 55154-1557; 63629-8103; 70934-351; 70518-3291; 71610-138; 52423-0915; 68788-7690; 63187-600; 70518-2437; 67296-0701; 67296-0729; 46708-851; 51407-111; 55154-5356; 43063-821; 68071-4880; 50090-1979; 61919-317; 68071-1950; 57664-162; 12666-0009; 71610-551; 65862-416
Synonyms Metoprolol | Toprol | Betaloc | Betaloc-Astra | Betaloc Astra | Betalok | CGP-2175 | CGP 2175 | CGP2175 | H 93-26 | H 93 26 | H 9326 | Metoprolol Tartrate | Seloken | Spesicor | Spesikor | Metoprolol Succinate | Metoprolol CR-XL | Metoprolol CR XL | Toprol-XL | Toprol XL | Beloc-Duriles | Beloc Duriles | Lopressor
Chemical Information
Molecular Formula C34H56N2O12
CAS Registry Number 56392-17-7
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(C(C(=O)O)O)(C(=O )O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Arthritis15.01.01.001--
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.003--
Atrioventricular block first degree02.03.01.004--
Atrioventricular block second degree02.03.01.005--
Blood alkaline phosphatase13.04.02.010--Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure systolic13.14.03.012--Not Available
Blood triglycerides increased13.12.03.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Catatonia19.11.01.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
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