Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoprolol
Drug ID BADD_D01445
Description Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
Indications and Usage For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Marketing Status Discontinued; Prescription
ATC Code C07AB02
DrugBank ID DB00264
KEGG ID D02358
MeSH ID D008790
PubChem ID 4171
TTD Drug ID D0I2MK
NDC Product Code 0615-8422; 71205-003; 46708-291; 62332-113; 46708-292; 62332-114; 0615-8423; 62207-970; 62332-112; 65977-0117; 0615-8421; 46708-290
Synonyms Metoprolol | Toprol | Betaloc | Betaloc-Astra | Betaloc Astra | Betalok | CGP-2175 | CGP 2175 | CGP2175 | H 93-26 | H 93 26 | H 9326 | Metoprolol Tartrate | Seloken | Spesicor | Spesikor | Metoprolol Succinate | Metoprolol CR-XL | Metoprolol CR XL | Toprol-XL | Toprol XL | Beloc-Duriles | Beloc Duriles | Lopressor
Chemical Information
Molecular Formula C15H25NO3
CAS Registry Number 51384-51-1
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac output decreased13.14.02.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000057%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000341%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000024%Not Available
Cataract06.06.01.001--
Catatonia19.11.01.001--Not Available
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral ischaemia17.08.01.005; 24.04.06.0030.000031%
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000186%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000465%Not Available
Chest X-ray abnormal13.19.02.0010.000031%Not Available
Chills15.05.03.016; 08.01.09.001--
Choking sensation22.02.05.002; 19.01.02.0020.000031%Not Available
Cholelithiasis09.03.01.0020.000062%Not Available
Cholestasis09.01.01.0010.000062%Not Available
Chromaturia20.02.01.0020.000078%
Chronic obstructive pulmonary disease22.03.01.0070.000093%Not Available
Circulatory collapse24.06.02.0010.000186%Not Available
Coagulopathy01.01.02.0010.000140%Not Available
Cold sweat08.01.03.024; 23.02.03.0020.000031%Not Available
Colitis07.08.01.0010.000047%
Coma17.02.09.0010.000113%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.000607%Not Available
Conduction disorder02.03.01.0080.000031%
Confusional state19.13.01.001; 17.02.03.0050.000481%
Congenital cystic kidney disease20.01.04.006; 16.27.01.002; 03.06.01.0030.000062%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 21 Pages