Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoprolol
Drug ID BADD_D01445
Description Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
Indications and Usage For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Marketing Status Discontinued; Prescription
ATC Code C07AB02
DrugBank ID DB00264
KEGG ID D02358
MeSH ID D008790
PubChem ID 4171
TTD Drug ID D0I2MK
NDC Product Code 0615-8422; 71205-003; 46708-291; 62332-113; 46708-292; 62332-114; 0615-8423; 62207-970; 62332-112; 65977-0117; 0615-8421; 46708-290
Synonyms Metoprolol | Toprol | Betaloc | Betaloc-Astra | Betaloc Astra | Betalok | CGP-2175 | CGP 2175 | CGP2175 | H 93-26 | H 93 26 | H 9326 | Metoprolol Tartrate | Seloken | Spesicor | Spesikor | Metoprolol Succinate | Metoprolol CR-XL | Metoprolol CR XL | Toprol-XL | Toprol XL | Beloc-Duriles | Beloc Duriles | Lopressor
Chemical Information
Molecular Formula C15H25NO3
CAS Registry Number 51384-51-1
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cyanosis neonatal22.11.02.003; 18.04.09.0060.000047%Not Available
Diverticulum intestinal haemorrhagic07.10.01.003; 24.07.02.0430.000031%Not Available
Laboratory test interference13.18.01.0080.000062%Not Available
Maternal drugs affecting foetus18.03.03.009; 12.03.03.0060.000279%Not Available
Nail psoriasis23.03.14.0090.000031%Not Available
Neonatal respiratory distress syndrome18.04.10.003; 22.11.02.0100.000093%Not Available
Normal newborn18.08.06.0010.000047%Not Available
Oxygen saturation abnormal13.02.01.0280.000031%Not Available
Persecutory delusion19.10.01.0070.000047%Not Available
Placental insufficiency18.05.02.006; 24.04.12.0020.000031%Not Available
Renal dysplasia03.06.01.013; 20.01.06.0130.000062%Not Available
Small for dates baby18.04.02.0020.000357%Not Available
Squamous cell carcinoma of the oral cavity07.21.07.009; 16.13.07.0060.000031%Not Available
Kidney enlargement20.01.06.0030.000031%Not Available
Feeling guilty19.15.02.0100.000062%Not Available
Neonatal tachycardia18.04.07.009; 02.03.02.0260.000047%Not Available
Renal impairment neonatal20.01.03.025; 18.04.01.0200.000031%Not Available
Mitochondrial cytopathy14.11.02.0080.000031%Not Available
Meconium in amniotic fluid18.05.01.0070.000031%Not Available
Bradycardia neonatal18.04.07.004; 02.03.02.0190.000062%Not Available
Nephrogenic anaemia20.01.01.007; 01.03.04.0010.000031%Not Available
General physical condition abnormal13.15.01.0400.000062%Not Available
Accidental death12.01.08.040; 08.04.01.0130.000008%Not Available
Uterine haematoma24.07.03.031; 21.07.01.0180.000031%Not Available
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.000031%Not Available
Vasoplegia syndrome24.06.03.011; 12.02.01.0100.000031%Not Available
Naevus flammeus24.03.03.036; 23.05.01.016; 03.05.01.0200.000093%Not Available
Delivery18.08.02.0060.000047%Not Available
Acute lung injury22.01.03.0100.000032%Not Available
Coma scale abnormal13.07.03.0120.000031%Not Available
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