Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metolazone
Drug ID BADD_D01444
Description A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss.
Indications and Usage For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Marketing Status Prescription; Discontinued
ATC Code C03BA08
DrugBank ID DB00524
KEGG ID D00431
MeSH ID D008788
PubChem ID 4170
TTD Drug ID D01WLC
NDC Product Code 76385-138; 0904-7139; 62332-533; 0185-5600; 0378-6174; 69575-4023; 46708-533; 43353-931; 0527-2215; 0185-0055; 60687-635; 69292-562; 72888-052; 71335-1944; 46708-532; 71610-286; 62332-532; 51407-432; 51407-431; 0904-7138; 60687-536; 63629-8733; 64330-115; 76385-136; 62332-534; 0527-2216; 72888-054; 60687-624; 63629-8722; 51407-433; 0378-6172; 65392-2201; 63629-7875; 69292-564; 60687-547; 46708-534; 71610-142; 43353-999; 72888-053; 0185-5050; 43353-890; 0527-2217; 69766-067; 71610-285; 0378-6173; 69292-566; 17381-254; 0904-6915; 51079-024; 51079-023; 0904-6916; 76385-137
Synonyms Metolazone | Microx | Mykrox | Zaroxolyn | Diulo | SR-720-22 | SR 720 22 | SR72022
Chemical Information
Molecular Formula C16H16ClN3O3S
CAS Registry Number 17560-51-9
SMILES CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Nocturia20.02.03.001--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Peripheral coldness08.01.09.010; 24.04.03.006--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Photosensitivity reaction23.03.09.003--
Pruritus23.03.12.001--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Shock24.06.02.002--Not Available
Sinus congestion22.04.06.001--Not Available
Skin exfoliation23.03.07.003--Not Available
Skin necrosis23.03.03.011--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Swelling08.01.03.015--Not Available
Syncope17.02.04.008; 02.01.02.008; 24.06.02.012--
Tension19.06.02.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Urticaria10.01.06.001; 23.04.02.001--
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