Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoclopramide hydrochloride
Drug ID BADD_D01443
Description Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.[L8417] One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]
Indications and Usage For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Marketing Status Prescription; Discontinued
ATC Code A03FA01
DrugBank ID DB01233
KEGG ID D02213
MeSH ID D008787
PubChem ID 23659
TTD Drug ID D08VYV
NDC Product Code 76045-213; 72089-307; 68071-4551; 0121-1576; 49452-4715; 0121-0576; 76045-101; 0404-9910; 55154-2353; 62559-166; 71872-7265; 55154-0450; 51552-1549; 51604-0005; 17856-0576; 68071-3262; 66689-031; 52584-414; 23155-240; 61919-150; 68788-6791; 40700-0010; 51927-5099; 43386-581; 43386-580; 51927-0185; 57451-1119; 57451-1139; 62559-165; 45562-1737; 76420-295
Synonyms Metoclopramide | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | Metaclopramide | Maxolon | Rimetin | Metoclopramide Hydrochloride | Hydrochloride, Metoclopramide | Metoclopramide Monohydrochloride | Monohydrochloride, Metoclopramide | Metoclopramide Monohydrochloride, Monohydrate | Primperan | Reglan | Cerucal | Metoclopramide Dihydrochloride | Dihydrochloride, Metoclopramide
Chemical Information
Molecular Formula C14H23Cl2N3O2
CAS Registry Number 2576-84-3
SMILES CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Laryngospasm22.04.02.002--
Leukopenia01.02.02.001--Not Available
Methaemoglobinaemia01.05.01.002--
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Opisthotonus17.01.03.005--Not Available
Pollakiuria20.02.02.007--
Porphyria14.14.01.001; 03.08.01.001--Not Available
Protrusion tongue17.02.05.037; 07.14.02.002--Not Available
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Stridor22.04.02.003--
Suicidal ideation19.12.01.003--
Sulphaemoglobinaemia01.05.01.003--Not Available
Supraventricular tachycardia02.03.03.012--
Tardive dyskinesia17.01.02.012--Not Available
Tetanus17.05.02.011; 11.02.02.007--Not Available
Tongue oedema07.14.02.007; 23.04.01.009; 10.01.05.008--Not Available
Torticollis17.01.03.003; 15.05.04.003--Not Available
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Visual impairment06.02.06.008--Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Grimacing17.02.05.029--Not Available
Functional gastrointestinal disorder07.11.01.016--Not Available
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