Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoclopramide
Drug ID BADD_D01442
Description Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.[L8417] One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]
Indications and Usage For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Marketing Status Prescription; Discontinued
ATC Code A03FA01
DrugBank ID DB01233
KEGG ID D00726
MeSH ID D008787
PubChem ID 4168
TTD Drug ID D08VYV
NDC Product Code 63187-404; 51079-888; 0093-2204; 51662-1367; 0615-8285; 63629-2144; 70518-0669; 42291-596; 60687-620; 55154-8196; 0409-3414; 43353-274; 51662-1288; 70518-1193; 66267-841; 71872-7075; 62559-190; 62559-295; 71872-7076; 68084-676; 60687-631; 71335-0362; 42291-595; 68788-7930; 50090-0132; 55154-4383; 66267-286; 49884-689; 68071-4569; 68788-7226; 0703-4502; 67296-0855; 62559-296; 63187-235; 0615-7698; 71335-0790; 0093-2203; 49999-057; 66267-827; 68071-4326; 51079-886; 50090-2221; 63629-7967; 63629-1961; 63629-8745
Synonyms Metoclopramide | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | Metaclopramide | Maxolon | Rimetin | Metoclopramide Hydrochloride | Hydrochloride, Metoclopramide | Metoclopramide Monohydrochloride | Monohydrochloride, Metoclopramide | Metoclopramide Monohydrochloride, Monohydrate | Primperan | Reglan | Cerucal | Metoclopramide Dihydrochloride | Dihydrochloride, Metoclopramide
Chemical Information
Molecular Formula C14H22ClN3O2
CAS Registry Number 364-62-5
SMILES CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blepharospasm17.17.02.001; 06.05.01.0010.000725%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood prolactin increased13.10.03.0020.000725%Not Available
Blood urea increased13.13.01.0060.000725%Not Available
Body temperature increased13.15.01.0010.000725%Not Available
Bradycardia02.03.02.002--Not Available
Bradykinesia17.01.02.0040.001812%Not Available
Breast enlargement21.05.04.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Bruxism19.11.03.001; 07.01.06.0080.003987%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure acute02.05.01.0050.002537%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.005799%Not Available
Cardiomyopathy02.04.01.0010.001087%Not Available
Cellulitis11.02.01.001; 23.09.01.001--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.0010.000725%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.000725%Not Available
Cholecystitis chronic09.03.01.0040.000725%Not Available
Cholinergic syndrome17.05.01.0020.000725%Not Available
Chorea17.01.01.0010.002899%Not Available
Clumsiness17.01.02.0050.000725%Not Available
Coagulopathy01.01.02.0010.001812%Not Available
Cogwheel rigidity15.05.04.006; 17.01.05.001--Not Available
Coma17.02.09.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
The 2th Page    First    Pre   2 3 4 5 6    Next   Last    Total 11 Pages