Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methysergide maleate
Drug ID BADD_D01440
Description An ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Indications and Usage For the treatment of vascular headache
Marketing Status Discontinued
ATC Code N02CA04
DrugBank ID DB00247
KEGG ID D00681
MeSH ID D008784
PubChem ID 5281073
TTD Drug ID D0O6GC
NDC Product Code Not Available
Synonyms Methysergide | Dimethylergometrin | Methylmethylergonovine | UML-491 | UML 491 | UML491 | Sansert | Deseril | Désernil-Sandoz | Désernil Sandoz | Desril | Methysergide Dimaleate | Dimaleate, Methysergide | Methysergide Maleate | Maleate, Methysergide
Chemical Information
Molecular Formula C25H31N3O6
CAS Registry Number 129-49-7
SMILES CCC(CO)NC(=O)C1CN(C2CC3=CN(C4=CC=CC(=C34)C2=C1)C)C.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Cardiac function disturbance postoperative12.02.01.004; 02.01.01.006--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Eosinophilia01.02.04.001--
Euphoric mood19.04.02.006--
Feeling abnormal08.01.09.014--Not Available
Fibrosis08.03.01.001--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Hyperaesthesia17.02.06.004--Not Available
Hypoaesthesia17.02.06.023--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Lung disorder22.02.07.001--Not Available
Myalgia15.05.02.001--
Mydriasis06.05.03.004; 17.02.11.003--Not Available
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain in extremity15.03.04.010--
Paraesthesia17.02.06.005--
Pulse abnormal13.14.04.004--Not Available
Pulse absent13.14.04.005--Not Available
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