Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylprednisolone
Drug ID BADD_D01433
Description Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone].[A188811] It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957.[L10785] In the outbreak of COVID-19, low dose methylprednisolone-based therapy was successful in treating COVID-19-associated pneumonia in one patient with long-term immunosuppression.[A192813] The efficacy of methylprednisolone in novel coronavirus pneumonia is being investigated further in clinical trials.[L12666]
Indications and Usage Adjunctive therapy for short-term administration in rheumatoid arthritis.
Marketing Status Prescription; Discontinued
ATC Code D07AA01; D10AA02; H02AB04
DrugBank ID DB00959
KEGG ID D00407
MeSH ID D008775
PubChem ID 6741
TTD Drug ID D08PIQ
NDC Product Code 69306-400; 0009-0038; 68071-5221; 71329-303; 68180-686; 57582-011; 0009-0022; 68788-4593; 22552-0029; 68382-918; 71329-305; 68180-687; 70121-1000; 82094-401; 70121-1001; 61919-149; 59746-002; 70518-1541; 68788-7833; 63629-2226; 45865-104; 68071-2370; 82094-405; 82094-403; 65162-980; 59762-0051; 70625-237; 63629-2218; 49999-153; 76420-041; 68071-2301; 59762-0049; 0009-0073; 76420-193; 68382-916; 59746-003; 71329-302; 82094-402; 71205-054; 63187-802; 59762-4440; 71205-453; 70771-1350; 59746-001; 71329-301; 70771-1351; 68180-689; 42806-400; 0781-5022; 72647-331; 60722-1003; 82094-404; 51552-0603; 68001-005; 51927-0201; 49452-4686; 68382-917; 70771-1348; 71329-304; 68382-919; 0603-4593; 65162-871; 59762-0050; 60760-373; 70786-0001; 65162-982; 70771-1349; 0009-0056; 50436-0001; 57582-101; 0009-0020; 0009-0176; 68071-4028; 59746-015; 64958-0084; 53002-3120; 82298-118; 63629-2433; 72189-264; 65162-984; 0904-6914; 69306-004; 63187-160; 50090-3811; 68084-149; 55289-649; 50090-0092; 45865-417; 50090-3094; 68180-688; 68180-685; 66267-961
Synonyms Methylprednisolone | Metipred | 6-Methylprednisolone | 6 Methylprednisolone | Urbason | Medrol
Chemical Information
Molecular Formula C22H30O5
CAS Registry Number 83-43-2
SMILES CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityTyrosine aminotransferaseP17735Not Available10485078; 10098101; 8719235; 1362219
HepatotoxicityGlucocorticoid receptorP04150T4001610485078; 10098101; 8719235; 1362219
Immune thrombocytopenic purpuraP-selectinP16109T10965Not Available
Immune thrombocytopenic purpuraInterleukin-6P05231T32578Not Available
Immune thrombocytopenic purpuraThrombopoietinP40225T99379Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.0010.001203%Not Available
Atrial fibrillation02.03.03.002--
Atrophy08.03.04.001--Not Available
Back pain15.03.04.0050.001415%
Benign intracranial hypertension17.07.02.001--Not Available
Blindness06.02.02.001; 17.17.01.003--Not Available
Blood calcium increased13.11.01.003--Not Available
Blood glucose abnormal13.02.02.0080.000283%Not Available
Blood glucose increased13.02.02.0020.000708%Not Available
Blood lactate dehydrogenase increased13.04.02.0020.000142%
Blood potassium decreased13.11.01.010--Not Available
Blood pressure decreased13.14.03.0020.000425%Not Available
Blood pressure increased13.14.03.0050.000920%Not Available
Bone pain15.02.01.0010.000142%
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.000212%
Burning sensation17.02.06.001; 08.01.09.029--Not Available
C-reactive protein increased13.09.01.0070.000354%Not Available
Calcinosis08.03.04.002--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
Cataract06.06.01.0010.000425%
Cataract subcapsular06.06.01.002--Not Available
Cerebral artery embolism24.01.04.001; 17.08.01.0010.000037%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000354%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000212%Not Available
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