| Drug Name |
Methimazole |
| Drug ID |
BADD_D01414 |
| Description |
Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949[A184502] and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.[L8336,L8339]
On a weight basis, methimazole is 10 times more potent than the other major antithyroid thionamide used in North America, [propylthiouracil],[L8339] and is the active metabolite of the pro-drug [carbimazole], which is an antithyroid medication used in the United Kingdom and parts of the former British Commonwealth.[A184733] Traditionally, methimazole has been preferentially used over propylthiouracil due to the risk of fulminant hepatotoxicity carried by the latter,[A184757] with propylthiouracil being preferred in pregnancy due to a perceived lower risk of teratogenic effects. Despite documented teratogenic effects in its published labels,[L8336,L8339] the true teratogenicity of methimazole appears to be unclear[A184643,A184757,A184763] and its place in therapy may change in the future. |
| Indications and Usage |
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
H03BB02 |
| DrugBank ID |
DB00763
|
| KEGG ID |
D00401
|
| MeSH ID |
D008713
|
| PubChem ID |
1349907
|
| TTD Drug ID |
D0S4BR
|
| NDC Product Code |
68071-5197; 38779-0360; 60429-380; 63629-2027; 63629-8347; 64980-260; 51927-1943; 71335-0883; 63629-9250; 63629-2026; 63629-9137; 50090-3334; 60687-357; 23155-070; 60429-381; 49884-640; 70518-1506; 63629-9251; 50090-2366; 51552-0822; 62991-1515; 70518-1475; 62135-206; 60687-370; 63629-2225; 66219-0253; 63629-9249; 0185-0205; 0185-0210; 54382-112; 23155-071; 63629-2224; 49884-641; 62135-205; 49452-4573; 64980-261; 63629-6408 |
| Synonyms |
Methimazole | 1-Methyl-2-mercaptoimidazole | 1 Methyl 2 mercaptoimidazole | Merkazolil | Tiamazol | Thiamazole | Thimazol | Mercasolyl | Mercazolyl | Methymazol | Methylmercaptoimidazole | Mercazol | Mercazole | Metisol | Metizol | Tapazole | Tirodril | Strumazol | Thiamazol Henning | Henning, Thiamazol | Thiamazol Hexal | Hexal, Thiamazol | Thyrozol | Favistan | Methizol |
