Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mercaptopurine
Drug ID BADD_D01392
Description An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Indications and Usage For remission induction and maintenance therapy of acute lymphatic leukemia.
Marketing Status approved
ATC Code L01BB02
DrugBank ID DB01033
KEGG ID D00161; D04931
MeSH ID D015122
PubChem ID 667490
TTD Drug ID D09UZO
NDC Product Code 62991-2899; 69076-913; 15308-0712; 12780-0299; 0054-4581; 0378-3547
UNII E7WED276I5
Synonyms Mercaptopurine | 6H-Purine-6-thione, 1,7-dihydro- | 6-Mercaptopurine Monohydrate | 6 Mercaptopurine Monohydrate | 6-Thiopurine | 6 Thiopurine | 1,7-Dihydro-6H-purine-6-thione | 6-Mercaptopurine | 6 Mercaptopurine | 6-Thiohypoxanthine | 6 Thiohypoxanthine | Purinethol | Puri-Nethol | Mercaptopurina Wellcome | Leupurin | BW 57-323H | BW 57 323H | BW 57323H | Purimethol | Mecaptopurine Anhydrous
Chemical Information
Molecular Formula C5H4N4S
CAS Registry Number 50-44-2
SMILES C1=NC2=C(N1)C(=S)N=CN2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal oedema07.11.01.0120.001041%Not Available
Female genital tract fistula21.10.05.009; 20.08.01.007; 07.11.05.004; 12.02.14.010; 23.07.04.015--Not Available
Skin plaque23.03.03.044--Not Available
Small intestine adenocarcinoma16.13.13.001; 07.21.01.0150.001561%Not Available
Drug effect less than expected08.06.01.036--Not Available
Gastrointestinal scarring07.13.01.015--Not Available
Haemophagocytic lymphohistiocytosis01.05.01.026; 16.32.03.038; 10.02.01.0770.002602%Not Available
Illness08.01.03.091--Not Available
Immune effector cell-associated neurotoxicity syndrome19.13.01.006; 17.13.01.015; 12.03.01.0650.001041%Not Available
Intestinal mucosal hypertrophy07.11.01.040--Not Available
Linitis plastica16.13.03.006; 07.21.02.0060.001561%Not Available
Metastases to rectum16.22.02.040; 07.21.01.0220.001561%Not Available
Myelosuppression01.03.03.0150.005725%Not Available
Salivary gland neoplasm16.13.14.001; 07.21.08.004--Not Available
Therapeutic product effect decreased08.06.01.050--Not Available
Therapeutic product effect incomplete08.06.01.052--Not Available
Therapeutic product ineffective08.06.01.057--Not Available
Therapeutic response shortened08.06.01.062--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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