Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Meprobamate
Drug ID BADD_D01390
Description A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S.
Indications and Usage For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.
Marketing Status Prescription; Discontinued
ATC Code N05BC01
DrugBank ID DB00371
KEGG ID D00376
MeSH ID D008620
PubChem ID 4064
TTD Drug ID D0Y4AW
NDC Product Code 62332-019; 69097-975; 51672-4148; 62332-020; 46708-850; 46708-019; 66064-4001; 66022-0105; 51672-4147; 69097-974; 46708-020
Synonyms Meprobamate | Miltown | Méprobamate Richard | Meprospan | Tranmep | Visano | Equanil | Dapaz
Chemical Information
Molecular Formula C9H18N2O4
CAS Registry Number 57-53-4
SMILES CCCC(C)(COC(=O)N)COC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Accommodation disorder06.02.04.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anuria20.01.03.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Body temperature increased13.15.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Chills15.05.03.016; 08.01.09.001--
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug eruption08.01.06.015; 23.03.05.001; 10.01.01.005--Not Available
Dysarthria19.19.03.001; 17.02.08.001--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.001--Not Available
Electroencephalogram abnormal13.07.03.001--Not Available
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Euphoric mood19.04.02.006--
Fixed drug eruption23.03.05.006; 10.01.01.022; 08.01.06.017--Not Available
Headache17.14.01.001--
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