Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mepivacaine
Drug ID BADD_D01387
Description A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Indications and Usage For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
Marketing Status Prescription; Discontinued
ATC Code N01BB03
DrugBank ID DB00961
KEGG ID D08181
MeSH ID D008619
PubChem ID 4062
TTD Drug ID D0WO8W
NDC Product Code 52932-0745
Synonyms Mepivacaine | Mepivacaina Braun | Isogaine | Meaverin | Mecain | Mepihexal | Mepivacain-Injektopas | Mepivacain Injektopas | Mepivacaine Hydrochloride | Mepivacaine Monohydrochloride | Mepivastesin | Polocaine | Scandinibsa | Scandonest | Scandicain | Scandicaine | Carbocaine | Carbocaïne | Isocaine
Chemical Information
Molecular Formula C15H22N2O
CAS Registry Number 96-88-8
SMILES CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tension19.06.02.005--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tremor17.01.06.002--
Unresponsive to stimuli17.02.05.0310.001182%Not Available
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.0010.000788%
Ventricular arrhythmia02.03.04.006--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.0030.000788%
Paraesthesia oral17.02.06.008; 07.05.03.003--Not Available
Pulseless electrical activity02.03.04.0200.000788%Not Available
Eye movement disorder06.05.02.008; 17.02.05.0250.000788%Not Available
Cranial nerve paralysis17.04.01.002--Not Available
Neonatal asphyxia22.11.02.006; 18.04.15.0050.000788%Not Available
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