Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Megestrol acetate
Drug ID BADD_D01372
Description 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Indications and Usage For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Marketing Status Prescription; Discontinued
ATC Code G03AC05; G03DB02; L02AB01
DrugBank ID DB00351
KEGG ID D00952
MeSH ID D019290
PubChem ID 11683
TTD Drug ID Not Available
NDC Product Code 49884-289; 0121-4776; 72969-102; 17856-0907; 49884-290; 0009-5030; 60429-433; 77044-5047; 24979-041; 51927-1670; 49884-230; 68094-361; 63629-7631; 0904-3571; 63739-549; 46439-8722; 0555-0607; 0121-0945; 63629-2221; 64380-158; 49884-907; 71205-943; 55154-5776; 63629-2219; 66689-020; 81646-120; 50383-859; 63629-2220; 60432-126; 51991-313; 0555-0606; 43744-363; 63592-0109; 64380-159; 68094-250; 0904-7072
Synonyms Megestrol Acetate | Acetate, Megestrol | Lin-Megestrol | Lin Megestrol | LinMegestrol | Maygace | Megace | Megostat | Megestat | Megefren | Mestrel | Nu-Megestrol | Nu Megestrol | NuMegestrol | Borea | Apo-Megestrol | Apo Megestrol | ApoMegestrol
Chemical Information
Molecular Formula C24H32O4
CAS Registry Number 595-33-5
SMILES CC1=CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypogonadism21.03.02.010; 05.05.04.0020.003945%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Ill-defined disorder08.01.03.049--Not Available
Candida infection11.03.03.021--
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