| Drug Name |
Mechlorethamine hydrochloride |
| Drug ID |
BADD_D01360 |
| Description |
A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.
The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCl. |
| Indications and Usage |
For the palliative treatment of Hodgkin's disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. Also for the palliative treatment of metastatic carcinoma resulting in effusion. |
| Marketing Status |
Prescription |
| ATC Code |
L01AA05 |
| DrugBank ID |
DB00888
|
| KEGG ID |
D04872
|
| MeSH ID |
D008466
|
| PubChem ID |
5935
|
| TTD Drug ID |
D03SSE
|
| NDC Product Code |
43744-364; 58272-198; 72969-043; 69639-120 |
| Synonyms |
Mechlorethamine | Chlormethine | Bis(2-chloroethyl)methylamine | Mustine | Nitrogen Mustard | Chlorethazine | Methylchlorethamine | Cloramin | Embichin | Mechlorethamine Hydrochloride | Hydrochloride, Mechlorethamine | Mechlorethamine Hydrochloride N-Oxide | Hydrochloride N-Oxide, Mechlorethamine | Mechlorethamine Hydrochloride N Oxide | N-Oxide, Mechlorethamine Hydrochloride | NSC-762 | NSC 762 | NSC762 | Mechlorethamine Oxide | Mitomen | Mustargen | Nitrogranulogen | Nitromin | NSC-10107 | NSC 10107 | NSC10107 | Caryolysine | Mechlorethamine N-Oxide | Mechlorethamine N Oxide | Nitrogen Mustard N-Oxide | N-Oxide, Nitrogen Mustard | Nitrogen Mustard N Oxide |
