Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Maraviroc
Drug ID BADD_D01352
Description Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Indications and Usage For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.
Marketing Status Prescription
ATC Code J05AX09
DrugBank ID DB04835
KEGG ID D06670
MeSH ID D000077592
PubChem ID 3002977
TTD Drug ID D0NR6S
NDC Product Code 69037-0062; 49702-223; 50923-0414; 12828-0091; 49702-260; 49702-235; 69037-0061; 31722-579; 49702-233; 31722-580; 68554-0040; 49702-237; 76072-1019; 49702-224
Synonyms Maraviroc | 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide | Selzentry | UK-427,857 | UK 427,857 | UK427,857 | UK-427857 | UK 427857 | UK427857
Chemical Information
Molecular Formula C29H41F2N5O
CAS Registry Number 376348-65-1
SMILES CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urine abnormality20.02.01.013--Not Available
Varicella11.05.02.004; 23.09.03.003--Not Available
Vascular purpura24.07.06.011; 23.06.01.008; 01.01.04.007--Not Available
Vasculitis24.05.02.001; 10.02.02.006--
Venous thrombosis24.01.01.008--Not Available
Viral infection11.05.04.001--Not Available
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Vomiting07.01.07.003--
Sinobronchitis22.07.03.025; 11.01.13.022--Not Available
Lipodystrophy acquired23.07.01.003; 14.08.04.008--Not Available
Lipase13.05.01.011--Not Available
Deep vein thrombosis24.01.02.0030.001447%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Metastases to peritoneum16.22.02.008; 07.21.03.003--Not Available
Gastrointestinal hypomotility07.02.02.005--Not Available
Lymphatic disorder01.09.01.003--Not Available
Paranasal sinus discomfort22.02.05.028--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Type IV hypersensitivity reaction10.01.03.022--Not Available
Transaminases increased13.03.01.015--Not Available
Bone cancer metastatic16.29.02.001; 15.09.03.004--Not Available
Hepatic cancer metastatic16.07.02.002; 09.04.02.006--Not Available
Varices oesophageal24.10.02.004; 09.01.06.009; 07.15.05.001--Not Available
Angiopathy24.03.02.007--Not Available
Anogenital warts23.10.01.003; 21.10.03.004; 16.26.01.003; 11.05.07.002; 07.19.04.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Drug resistance08.06.01.0050.001698%Not Available
Urine output increased13.13.03.002--Not Available
Tinea infection23.09.02.004; 11.03.08.002--Not Available
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