Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Macitentan
Drug ID BADD_D01336
Description Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension.[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity.
Indications and Usage Macitentan is indicated for patients with pulmonary arterial hypertension.
Marketing Status Prescription
ATC Code C02KX04
DrugBank ID DB08932
KEGG ID D10135
MeSH ID C533860
PubChem ID 16004692
TTD Drug ID D0S7JH
NDC Product Code 11722-058; 65015-872; 69766-006; 68225-070; 82245-0117; 69037-0030; 66215-501; 76397-014; 46708-893; 59651-122
Synonyms macitentan | N-(5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)pyrimidin-4-yl)-N'-propylaminosulfonamide | ACT 064992 | ACT064992 | ACT-064992 | Actelion-1 | opsumit
Chemical Information
Molecular Formula C19H20Br2N6O4S
CAS Registry Number 441798-33-0
SMILES CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Decreased activity08.01.01.006; 19.11.01.0020.000577%Not Available
Decubitus ulcer23.03.11.0060.001443%Not Available
Dehydration14.05.05.0010.017609%
Delirium19.13.02.001--
Dementia19.20.02.001; 17.03.01.0010.003175%Not Available
Dental caries07.09.01.001--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Diabetes mellitus14.06.01.001; 05.06.01.0010.004907%Not Available
Diabetic neuropathy17.09.04.002; 14.07.04.003; 05.07.04.0030.001443%Not Available
Diarrhoea07.02.01.001--
Dilatation ventricular02.04.02.0260.000577%Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Diverticulitis11.01.07.003; 07.10.02.0010.004041%Not Available
Dizziness17.02.05.003; 24.06.02.007; 02.01.02.0040.047054%
Dizziness postural24.06.02.008; 17.02.05.004; 02.01.02.0050.000866%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dry throat22.02.05.004; 07.06.01.0050.000577%Not Available
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyskinesia17.01.02.006--
Dyslexia19.21.01.003; 17.02.03.0090.000577%Not Available
Dyspepsia07.01.02.0010.008949%
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