Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorazepam
Drug ID BADD_D01318
Description Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.[A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095]
Indications and Usage For the management of anxiety disorders, and for treatment of status epilepticus.
Marketing Status Prescription; Discontinued
ATC Code N05BA06
DrugBank ID DB00186
KEGG ID D00365
MeSH ID D008140
PubChem ID 3958
TTD Drug ID D0E0OG
NDC Product Code 55700-778; 0904-6009; 55289-402; 53002-7721; 52427-663; 0641-6046; 0641-6051; 72572-380; 0409-6778; 60687-638; 68071-5068; 0591-0242; 60687-401; 54348-049; 53002-5291; 69315-905; 76329-8261; 70518-2239; 68788-7480; 52696-0002; 0093-3425; 53002-5290; 61919-607; 13107-085; 0641-6048; 70518-2442; 55289-487; 68071-5137; 51927-1005; 0641-6207; 71610-600; 72166-001; 54348-028; 0641-6003; 71610-122; 67296-1332; 0591-0241; 43063-048; 43063-057; 55154-7976; 0409-6779; 0904-6007; 69315-906; 63629-8185; 0641-6047; 12828-0025; 67296-1629; 71610-178; 55700-745; 70518-1520; 68788-7428; 0641-6049; 65162-017; 70518-0486; 71610-255; 68071-2666; 0641-6001; 50090-0273; 70518-3225; 0409-1985; 76420-296; 45865-499; 67544-142; 0615-8077; 65162-018; 0641-6044; 48087-0076; 65162-015; 50090-0272; 50090-4001; 0409-1539; 68071-5084; 51927-0195; 0409-6780; 71610-199; 52427-667; 0615-8075; 72789-197; 50090-5508; 67296-1622; 60687-355; 67763-101; 50383-705; 68071-5022; 0641-6000; 49452-4140; 71205-228; 58118-1095; 63187-536; 68788-7533; 71335-0655; 13107-084; 13107-083; 70518-3188; 71205-166; 61919-062; 63629-2953; 68071-5061; 68071-5048; 71335-0329; 58118-1096; 70518-0445; 0591-0240; 0641-6045; 71610-229; 0641-6050; 62991-1682; 69315-904; 71335-1694; 68071-4882; 0054-3532; 63187-576; 71554-009; 53002-6290; 50090-4191; 68071-3096; 58118-0904; 60760-516; 50090-4157; 50090-5509; 60687-627; 71335-1467; 0187-0065; 72789-236; 17856-2059; 52427-661; 72789-226; 0093-3426; 50090-5081; 43353-255; 68071-4918; 71610-008; 0641-6002; 68071-3242; 71335-1138; 70518-2268; 68071-3227; 0093-3427; 68788-7355; 68071-2662; 63275-9979; 0121-0770; 0615-8076; 67544-191; 38779-0927; 0395-8161; 68071-4916; 70518-2186; 71610-225; 55154-7975; 70518-0275; 52427-658; 68071-5250; 50090-2810; 17478-040; 60687-649; 65162-687; 0187-0063; 51552-0729; 64330-020; 71205-235; 68071-3121; 67296-0143; 50090-3462; 67544-261; 17856-3532; 0904-6008; 57218-950; 0187-0064
Synonyms Lorazepam | Ativan | Orfidal Wyeth | Wyeth, Orfidal | Témesta | Tolid | Donix | Duralozam | Durazolam | Idalprem | Laubeel | Lorazep Von Ct | Von Ct, Lorazep | Lorazepam Medical | Medical, Lorazepam | Lorazepam-Neuraxpharm | Lorazepam Neuraxpharm | Lorazepam-Ratiopharm | Lorazepam Ratiopharm | Novo-Lorazem | Novo Lorazem | Nu-Loraz | Nu Loraz | Sedicepan | Sinestron | WY-4036 | WY 4036 | WY4036 | Apo-Lorazepam | Apo Lorazepam | Somagerol | Temesta
Chemical Information
Molecular Formula C15H10Cl2N2O2
CAS Registry Number 846-49-1
SMILES C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction08.02.03.014; 12.07.03.015--
Insomnia19.02.01.002; 17.15.03.0020.001611%
Instillation site pain12.07.01.008; 08.02.01.008--Not Available
Intentional self-injury12.01.08.036; 19.12.01.0020.004161%Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.0020.000134%Not Available
Irritability19.04.02.013; 08.01.03.0110.000805%
Jaundice09.01.01.004; 23.03.03.030; 01.06.04.0040.000604%Not Available
Laceration23.03.11.004; 12.01.06.0060.000201%Not Available
Lacrimation increased06.08.02.0040.000134%
Lactic acidosis14.01.01.002--Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.0030.000268%
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.0040.000872%
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Lipase increased13.05.01.0030.000134%
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.0130.000134%Not Available
Loss of consciousness17.02.04.0040.002147%Not Available
Malaise08.01.01.003--
Mania19.16.02.0020.000403%
Memory impairment19.20.01.003; 17.03.02.0030.000671%
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.0020.000201%Not Available
Metabolic acidosis14.01.01.0030.000470%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Miosis17.02.11.002; 06.05.03.0030.000805%Not Available
Mood altered19.04.02.007--Not Available
Mood swings19.04.03.0010.000140%Not Available
Movement disorder17.01.02.010--Not Available
The 8th Page    First    Pre   8 9 10 11 12    Next   Last    Total 16 Pages