Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorazepam
Drug ID BADD_D01318
Description Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic.[A957] It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095]
Indications and Usage For the management of anxiety disorders, and for treatment of status epilepticus.
Marketing Status Prescription; Discontinued
ATC Code N05BA06
DrugBank ID DB00186
KEGG ID D00365
MeSH ID D008140
PubChem ID 3958
TTD Drug ID D0E0OG
NDC Product Code 55700-778; 0904-6009; 55289-402; 53002-7721; 52427-663; 0641-6046; 0641-6051; 72572-380; 0409-6778; 60687-638; 68071-5068; 0591-0242; 60687-401; 54348-049; 53002-5291; 69315-905; 76329-8261; 70518-2239; 68788-7480; 52696-0002; 0093-3425; 53002-5290; 61919-607; 13107-085; 0641-6048; 70518-2442; 55289-487; 68071-5137; 51927-1005; 0641-6207; 71610-600; 72166-001; 54348-028; 0641-6003; 71610-122; 67296-1332; 0591-0241; 43063-048; 43063-057; 55154-7976; 0409-6779; 0904-6007; 69315-906; 63629-8185; 0641-6047; 12828-0025; 67296-1629; 71610-178; 55700-745; 70518-1520; 68788-7428; 0641-6049; 65162-017; 70518-0486; 71610-255; 68071-2666; 0641-6001; 50090-0273; 70518-3225; 0409-1985; 76420-296; 45865-499; 67544-142; 0615-8077; 65162-018; 0641-6044; 48087-0076; 65162-015; 50090-0272; 50090-4001; 0409-1539; 68071-5084; 51927-0195; 0409-6780; 71610-199; 52427-667; 0615-8075; 72789-197; 50090-5508; 67296-1622; 60687-355; 67763-101; 50383-705; 68071-5022; 0641-6000; 49452-4140; 71205-228; 58118-1095; 63187-536; 68788-7533; 71335-0655; 13107-084; 13107-083; 70518-3188; 71205-166; 61919-062; 63629-2953; 68071-5061; 68071-5048; 71335-0329; 58118-1096; 70518-0445; 0591-0240; 0641-6045; 71610-229; 0641-6050; 62991-1682; 69315-904; 71335-1694; 68071-4882; 0054-3532; 63187-576; 71554-009; 53002-6290; 50090-4191; 68071-3096; 58118-0904; 60760-516; 50090-4157; 50090-5509; 60687-627; 71335-1467; 0187-0065; 72789-236; 17856-2059; 52427-661; 72789-226; 0093-3426; 50090-5081; 43353-255; 68071-4918; 71610-008; 0641-6002; 68071-3242; 71335-1138; 70518-2268; 68071-3227; 0093-3427; 68788-7355; 68071-2662; 63275-9979; 0121-0770; 0615-8076; 67544-191; 38779-0927; 0395-8161; 68071-4916; 70518-2186; 71610-225; 55154-7975; 70518-0275; 52427-658; 68071-5250; 50090-2810; 17478-040; 60687-649; 65162-687; 0187-0063; 51552-0729; 64330-020; 71205-235; 68071-3121; 67296-0143; 50090-3462; 67544-261; 17856-3532; 0904-6008; 57218-950; 0187-0064
Synonyms Lorazepam | Ativan | Orfidal Wyeth | Wyeth, Orfidal | Témesta | Tolid | Donix | Duralozam | Durazolam | Idalprem | Laubeel | Lorazep Von Ct | Von Ct, Lorazep | Lorazepam Medical | Medical, Lorazepam | Lorazepam-Neuraxpharm | Lorazepam Neuraxpharm | Lorazepam-Ratiopharm | Lorazepam Ratiopharm | Novo-Lorazem | Novo Lorazem | Nu-Loraz | Nu Loraz | Sedicepan | Sinestron | WY-4036 | WY 4036 | WY4036 | Apo-Lorazepam | Apo Lorazepam | Somagerol | Temesta
Chemical Information
Molecular Formula C15H10Cl2N2O2
CAS Registry Number 846-49-1
SMILES C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bradypnoea22.02.01.0020.000403%Not Available
Bronchopulmonary dysplasia22.11.01.001; 18.04.10.0010.000035%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
C-reactive protein increased13.09.01.0070.000403%Not Available
Cardiac arrest02.03.04.0010.000403%
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000105%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000134%Not Available
Catatonia19.11.01.0010.001812%Not Available
Cerebellar syndrome17.02.02.0020.000134%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000805%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.0010.000403%
Choking sensation22.02.05.002; 19.01.02.0020.000134%Not Available
Cholecystitis09.03.01.0010.000403%
Chromaturia20.02.01.0020.000134%
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Circulatory collapse24.06.02.0010.000035%Not Available
Coagulopathy01.01.02.001--Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000201%Not Available
Colitis ischaemic24.04.08.012; 07.08.01.0040.000134%Not Available
Coma17.02.09.0010.002819%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.001523%Not Available
Concussion17.11.01.004; 12.01.10.0050.000134%Not Available
Confusional state19.13.01.001; 17.02.03.0050.006979%
Constipation07.02.02.001--
Cough22.02.03.001--
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.000201%Not Available
Cystitis20.03.02.002; 11.01.14.001--
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