Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loratadine
Drug ID BADD_D01317
Description Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis.[A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.[A176441]
Indications and Usage A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
Marketing Status OTC; Discontinued
ATC Code R06AX13
DrugBank ID DB00455
KEGG ID D00364
MeSH ID D017336
PubChem ID 3957
TTD Drug ID D06ABF
NDC Product Code 51672-2085; 71335-1461; 52904-630; 72288-446; 21130-452; 55910-807; 63868-462; 0363-2131; 36800-363; 51660-754; 61474-4268; 50090-1454; 70000-0473; 61919-142; 67751-153; 55910-594; 24385-543; 11523-4329; 71335-0100; 37012-612; 67091-245; 11523-4359; 11523-7333; 0363-1612; 41250-612; 16714-898; 70518-2951; 54838-558; 54838-554; 63868-577; 53943-035; 49452-4135; 62207-787; 72288-901; 0363-0858; 24385-531; 56062-132; 81646-106; 11523-7157; 49348-818; 73581-203; 69168-414; 51927-4219; 68391-314; 11014-0031; 70000-0125; 50090-4316; 53943-975; 68071-4910; 30142-612; 41250-629; 55910-539; 50268-489; 11673-997; 21130-999; 71335-1651; 65015-803; 59556-301; 11523-4328; 63940-904; 56062-526; 66267-653; 68210-4110; 11523-1527; 79481-0446; 62938-0005; 71610-423; 55700-097; 80070-110; 0363-9995; 11822-3276; 0363-4020; 55154-4375; 68196-301; 68788-7653; 51660-753; 11822-0558; 55910-970; 0113-1191; 51079-246; 69842-337; 68016-131; 46122-539; 41163-364; 55910-612; 71309-007; 68016-167; 67751-163; 69842-085; 49035-953; 70677-0029; 41520-510; 59556-882; 63941-193; 25000-021; 50090-0836; 51672-2108; 59651-074; 51672-2092; 58602-830; 0904-6767; 55319-099; 73629-003; 70518-1335; 62993-0801; 37808-131; 72036-193; 63868-414; 11822-0446; 63941-131; 30142-723; 55910-611; 36800-755; 57344-193; 63187-100; 10888-8213; 11673-115; 53002-7490; 72983-501; 51001-2213; 63827-0001; 11822-2131; 11523-7202; 11523-6655; 70518-1399; 68071-4318; 70010-162; 0363-2108; 69842-686; 80159-103; 69230-322; 58602-821; 71610-553; 68071-4121; 30142-066; 0363-0699; 53117-407; 51660-527; 0615-8217; 59556-917; 0363-9603; 51660-112; 60000-950; 41163-633; 66577-046; 0113-0671; 53943-193; 11523-4331; 70677-0134; 66577-012; 50090-4300; 11523-7160; 50090-5532; 0113-1612; 62011-0371; 21130-139; 11523-7200; 0904-6852; 69842-894; 21130-301; 69842-540; 68788-7291; 68016-094; 50090-4266; 68554-0003; 41250-890; 65015-684; 53117-309; 41520-612; 41226-686; 49035-806; 68788-7769; 71141-132; 70677-0145; 63941-526; 70518-0135; 69842-954; 56062-990; 51660-106; 69842-895; 0363-1686; 0363-0754; 11673-996; 62011-0248; 55681-303; 11523-4360; 41250-716; 47682-913; 80070-120; 56062-900; 49035-061; 72288-612; 68071-2392; 63654-309; 51672-2131; 55910-629; 0904-6632; 38779-2857; 50090-2387; 0363-0752; 45802-650; 68391-301; 57243-200; 0113-7612; 65691-0042; 11523-0007; 30142-984; 21130-646; 36800-853; 68071-3208; 51316-502; 0113-9755; 37808-529; 55301-612; 17856-0557; 70000-0583; 69842-953; 59726-915; 54473-166; 11673-111; 37205-378; 62938-0004; 68210-4126; 55289-728; 0113-7671; 41163-612; 36800-608; 58602-744; 63552-038; 72983-500; 63629-7772; 68998-309; 70000-0252; 43353-259; 51672-2073; 59726-758; 63868-669; 49035-538; 59651-035; 55154-4976; 69168-407; 0113-7500; 37808-506; 16571-822; 59779-528; 63629-1329; 69848-019; 11822-7240; 69842-535; 11822-8329; 68001-438; 0113-1719; 0363-9150; 69842-242; 50090-5506; 41520-716; 11523-7237; 70000-0213; 50090-5067; 41250-539; 67091-350; 68998-407; 69452-283; 69168-309; 68071-5049; 72888-029; 68071-2208; 0113-0612; 67091-246; 11523-0800; 30142-996; 63548-0753; 62331-018; 0536-1092; 55315-528; 53943-116; 50090-3464; 51316-503; 50090-3943; 68016-053; 65015-802; 68016-088; 51824-075; 58602-831; 63981-612; 62011-0348; 69452-211; 46122-423; 21130-123; 68016-055; 72288-200; 50804-840; 81522-612; 69256-612; 51660-526; 11822-2022; 55154-8082; 11673-986; 11523-4330; 11822-0919
Synonyms Loratadine | 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester | Claritin | Sch-29851 | Sch 29851 | Sch29851 | Alavert | Clarium
Chemical Information
Molecular Formula C22H23ClN2O2
CAS Registry Number 79794-75-5
SMILES CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000728%
Abdominal pain upper07.01.05.003--
Agitation19.06.02.001; 17.02.05.012--
Alopecia23.02.02.001--
Anaemia01.03.02.0010.000146%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.0020.000510%
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.0010.000291%
Arthritis15.01.01.0010.000219%
Asthenia08.01.01.0010.000291%Not Available
Back pain15.03.04.0050.000219%
Blister23.03.01.001; 12.01.06.002--Not Available
Blood pressure increased13.14.03.0050.000146%Not Available
Blood triglycerides increased13.12.03.0010.000146%Not Available
Body temperature increased13.15.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cataract06.06.01.0010.000146%
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000146%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000437%Not Available
Chromaturia20.02.01.002--
Colitis07.08.01.0010.000146%
Colitis ulcerative10.02.01.004; 07.08.01.0050.000364%Not Available
Confusional state17.02.03.005; 19.13.01.0010.000364%
Conjunctivitis11.01.06.012; 06.04.01.0020.000146%
Constipation07.02.02.0010.000219%
Cough22.02.03.0010.000291%
Crohn's disease10.02.01.005; 07.08.01.0150.000219%Not Available
Deafness04.02.01.0010.000219%Not Available
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