Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide
Drug ID BADD_D01311
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status Prescription
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09637
MeSH ID C473731
PubChem ID 9853053
TTD Drug ID D0H8VY
NDC Product Code Not Available
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C39H37F6N3O2
CAS Registry Number 182431-12-5
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
TeratogenicityCytochrome P450 3A4P08684T3784826240881
TeratogenicityATP-binding cassette subfamily B member 1AQ9JK64Not Available26240881
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
International normalised ratio decreased13.01.02.0070.000121%Not Available
International normalised ratio increased13.01.02.008--
Joint stiffness15.01.02.0030.000121%Not Available
Joint swelling15.01.02.004--Not Available
Laboratory test abnormal13.18.01.0010.000362%Not Available
Laryngeal pain22.02.05.036--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Lipids increased13.12.02.0040.000121%Not Available
Liver disorder09.01.08.0010.000362%Not Available
Liver function test abnormal13.03.01.0130.001086%Not Available
Loss of consciousness17.02.04.004--Not Available
Low density lipoprotein abnormal13.12.01.0120.000121%Not Available
Low density lipoprotein increased13.12.01.0050.002534%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.000181%Not Available
Malaise08.01.01.0030.002715%
Middle insomnia19.02.01.003; 17.15.03.0030.000181%Not Available
Migraine24.03.05.003; 17.14.02.0010.000181%Not Available
Muscle atrophy17.05.03.004; 15.05.03.0030.000121%Not Available
Muscle spasms15.05.03.0040.001086%
Muscle twitching15.05.03.005--Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.000362%
Musculoskeletal pain15.03.04.0070.000362%
Myalgia15.05.02.0010.000905%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.0010.000241%
Nasopharyngitis11.01.13.002; 22.07.03.0020.001207%Not Available
Nausea07.01.07.0010.006215%
Neck pain15.03.04.0090.000302%
Nervous system disorder17.02.10.001--Not Available
Neutrophil count decreased13.01.06.010--
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