Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide
Drug ID BADD_D01311
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status approved; investigational
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09637
MeSH ID C473731
PubChem ID 9853053
TTD Drug ID D0H8VY
NDC Product Code Not Available
UNII 82KUB0583F
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C39H37F6N3O2
CAS Registry Number 182431-12-5
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pollakiuria20.02.02.0070.000120%
Proctalgia07.03.02.001--
Prothrombin level increased13.01.02.011--Not Available
Rash erythematous23.03.13.029--Not Available
Renal cyst20.01.04.001; 16.27.01.0010.000032%Not Available
Renal disorder20.01.02.0020.000069%Not Available
Rhinorrhoea22.12.03.0210.000193%
Rotator cuff syndrome12.01.07.018; 15.01.08.0020.000047%
Sinus headache22.12.03.022; 17.14.01.0020.000073%
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.000073%
Somnolence17.02.04.006; 19.02.05.003--
Stress19.06.02.0040.000109%Not Available
Therapeutic response unexpected08.06.01.0010.000047%Not Available
Throat irritation22.12.03.029; 07.05.05.0370.000073%Not Available
Throat tightness19.01.02.005; 22.12.03.0310.000073%Not Available
Toothache07.09.06.0010.000156%
Trigeminal neuralgia17.04.08.0010.000109%Not Available
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Vertigo17.02.12.002; 04.04.01.0030.000094%
Vomiting07.01.07.0030.001298%
Weight decreased13.15.01.005--
White blood cell count decreased13.01.06.012--
White blood cell count increased13.01.06.013--Not Available
Xanthoma23.03.03.047; 14.08.04.0100.000109%Not Available
Mobility decreased17.02.05.018; 08.01.03.030; 15.03.05.0230.000084%Not Available
Musculoskeletal disorder15.03.05.025--Not Available
Weight fluctuation14.03.02.0020.000266%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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