Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomitapide
Drug ID BADD_D01311
Description Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Indications and Usage Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Marketing Status Prescription
ATC Code C10AX12
DrugBank ID DB08827
KEGG ID D09637
MeSH ID C473731
PubChem ID 9853053
TTD Drug ID D0H8VY
NDC Product Code Not Available
Synonyms BMS201038 | BMS-201038 | BMS 201038 | lomitapide | Juxtapid | AEGR 733 | AEGR733 | AEGR-733
Chemical Information
Molecular Formula C39H37F6N3O2
CAS Registry Number 182431-12-5
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C (=O)NCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
TeratogenicityATP-binding cassette subfamily B member 1AQ9JK64Not Available26240881
TeratogenicityCytochrome P450 3A4P08684T3784826240881
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastroenteritis07.19.03.001; 11.01.07.004--Not Available
Gastroenteritis viral11.05.04.005; 07.19.03.0050.000664%Not Available
Gastrointestinal disorder07.11.01.0010.001871%Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal infection07.19.02.005; 11.01.07.012--Not Available
Gastrointestinal pain07.01.05.0050.000121%
Glycosylated haemoglobin increased13.02.02.0050.000181%Not Available
Gout15.01.06.001; 14.09.01.0010.000302%Not Available
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemorrhoids07.15.03.001; 24.10.02.0020.000121%
Headache17.14.01.001--
Hepatic steatosis14.08.04.005; 09.01.07.0030.000422%Not Available
Hepatomegaly09.01.05.001--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hernia08.01.04.0010.000181%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.000181%
High density lipoprotein decreased13.12.01.0030.000362%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypotension24.06.03.002--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.0010.001026%Not Available
Influenza like illness08.01.03.0100.000543%
Insomnia19.02.01.002; 17.15.03.0020.000784%
International normalised ratio abnormal13.01.02.029--Not Available
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