Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lithium carbonate
Drug ID BADD_D01303
Description Lithium has been used to treat manic episodes since the 19th century[A176642]. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Indications and Usage Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
Marketing Status Prescription; Discontinued
ATC Code N05AN01
DrugBank ID DB14509
KEGG ID D00801
MeSH ID D016651
PubChem ID 11125
TTD Drug ID D04UUH
NDC Product Code 72789-173; 68462-222; 71610-557; 0220-3128; 0054-2531; 31722-546; 68462-224; 0054-0021; 71335-0120; 64117-256; 50090-1470; 46708-303; 70518-0437; 51079-180; 0054-8527; 0054-8526; 0054-2527; 62559-280; 0054-0020; 50090-2799; 0378-1450; 68084-655; 51079-142; 0378-1300; 68462-221; 0054-4527; 70518-0904; 50090-2959; 46708-304; 68084-640; 71335-1067; 0220-3129; 63629-7730; 66039-947; 58118-0545; 70518-0668; 62332-013; 72789-174; 50090-2754; 73309-248; 63629-1916; 64980-278; 82388-001; 0054-2526; 70518-2312; 63629-8282; 63629-1917; 55154-4920; 68428-481; 62332-014; 62756-430; 0054-8528; 70518-0608; 64980-205; 42291-496; 62332-015; 70518-2345; 68462-220; 50090-3918; 23155-763; 68788-7716; 0220-3131; 63187-304; 70518-1753; 71335-1006; 46708-305; 46708-148; 70518-2086; 62332-148; 31722-544; 63629-7903; 68462-223; 72789-171; 72789-172; 50090-3917; 0615-8302; 70518-2699; 0054-8531; 39345-5104; 43063-901; 70518-1434; 31722-545
Synonyms Lithium Carbonate | Carbonate, Lithium | Dilithium Carbonate | Carbonate, Dilithium | Lithane | Lithium Bicarbonate | Bicarbonate, Lithium | Lithobid | Lithonate | CP-15,467-61 | CP 15,467 61 | CP15,46761 | Micalith | NSC-16895 | NSC 16895 | NSC16895 | Priadel | Quilinorm-retard | Quilinorm retard | Quilinormretard | Eskalith | Lithotabs
Chemical Information
Molecular Formula CLi2O3
CAS Registry Number 554-13-2
SMILES [Li+].[Li+].C(=O)([O-])[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Nephrogenic diabetes insipidusVasopressin V2 receptorP48044Not AvailableNot Available
Renal aplasiaVasopressin V2 receptorP48044Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Joint hyperextension15.01.08.003; 12.04.03.004--Not Available
Unevaluable event08.01.03.051--Not Available
Chronic kidney disease20.01.03.0170.024939%
Bone marrow failure01.03.03.0050.000818%
Substance abuse19.07.02.0060.000818%Not Available
Renal cell carcinoma20.01.04.003; 16.08.02.0020.000533%Not Available
Acute kidney injury20.01.03.0160.010221%
Toxicity to various agents12.03.01.046--Not Available
Posterior reversible encephalopathy syndrome17.13.02.0070.000818%
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.001227%Not Available
Sinus node dysfunction02.03.03.017--
Multiple organ dysfunction syndrome08.01.03.0570.000213%
Anal incontinence17.05.01.021; 07.01.06.029--
Carcinoembryonic antigen increased13.22.01.0090.000818%Not Available
Ebstein's anomaly03.07.05.013; 02.08.01.0060.000818%Not Available
Maternal drugs affecting foetus18.03.03.009; 12.03.03.0060.000818%Not Available
Cardiomyopathy acute02.04.01.0080.000818%Not Available
Renal oncocytoma20.01.04.019; 16.27.01.0080.000427%Not Available
Self esteem inflated19.05.02.0030.000818%Not Available
Impaired self-care19.01.02.014; 08.01.03.0710.001227%Not Available
Sopor19.02.04.002; 17.02.04.0210.000818%Not Available
Antipsychotic drug level above therapeutic13.17.01.0270.004497%Not Available
Antipsychotic drug level below therapeutic13.17.01.0280.002044%Not Available
Congenital cardiovascular anomaly03.07.10.001; 02.08.02.004; 24.03.03.0110.000818%Not Available
Antipsychotic drug level increased13.17.01.0300.008177%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000818%Not Available
Septic encephalopathy17.13.02.011; 11.01.11.0160.000213%Not Available
Coma scale abnormal13.07.03.0120.001635%Not Available
Clear cell renal cell carcinoma20.01.04.008; 16.08.02.0040.001635%Not Available
End stage renal disease20.01.03.0190.005315%Not Available
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