Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lisinopril
Drug ID BADD_D01300
Description Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs.[A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.[A184844] Lisinopril was granted FDA approval on 29 December 1987.[L8384]
Indications and Usage For the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
Marketing Status Prescription; Discontinued
ATC Code C09AA03
DrugBank ID DB00722
KEGG ID D00362
MeSH ID D017706
PubChem ID 5362119
TTD Drug ID D07HGR
NDC Product Code 0615-8253; 69117-0037; 63187-775; 76282-418; 0615-8255; 50090-5122; 64220-142; 55289-884; 0615-8254; 68071-1775; 68788-6920; 61919-746; 68071-3123; 71335-0075; 0143-9715; 61919-717; 70518-1316; 0904-6799; 43353-993; 68071-1843; 72865-211; 72865-209; 68645-532; 68071-5190; 70518-1565; 63629-8082; 68071-1672; 63187-534; 65862-042; 0591-0409; 68788-7966; 64679-927; 51655-399; 43547-417; 53002-1178; 50090-2988; 50090-3774; 50436-0352; 43063-480; 43063-074; 55154-2128; 68001-336; 68084-196; 68071-5098; 68788-7831; 61919-942; 55154-8096; 64220-154; 68071-4858; 68071-4871; 42708-096; 68071-5077; 70882-110; 63187-722; 58118-1980; 42708-033; 76282-417; 43353-643; 71610-312; 0591-0408; 68071-3122; 50090-4678; 68001-333; 60760-357; 51655-411; 63629-1761; 60760-360; 52427-441; 64679-928; 50090-2228; 0143-9714; 0591-0885; 31722-179; 43353-297; 0591-0406; 42708-094; 64679-953; 67046-424; 71610-624; 55154-4682; 0185-0605; 50090-2934; 70518-1906; 68645-593; 61919-561; 43547-355; 65862-041; 70518-1156; 0591-0405; 51655-273; 50090-3763; 43547-418; 52427-439; 16729-380; 51655-232; 63187-442; 69117-0015; 68001-334; 43547-415; 71205-626; 0185-0640; 63629-7445; 68071-5143; 69117-0012; 72865-210; 72789-101; 43547-419; 71610-616; 50090-4485; 0904-6800; 65862-039; 65977-0009; 72865-213; 43547-356; 68788-7666; 0904-6797; 52652-3001; 0615-8256; 43547-354; 42708-142; 61919-736; 71610-612; 43063-814; 63187-098; 58118-1981; 50090-3765; 68180-517; 68180-981; 43353-009; 68071-1894; 0615-8252; 69117-0038; 68001-337; 53002-1123; 61919-721; 68071-5090; 71335-0498; 63629-2688; 0615-8405; 72789-093; 68788-7012; 35356-879; 71205-071; 43353-113; 63187-821; 0185-0610; 43353-298; 0591-0407; 68001-332; 50090-4725; 50090-4885; 72969-092; 54458-873; 61919-307; 50090-4887; 70518-3166; 43063-813; 68071-3178; 31722-178; 54458-874; 70518-0701; 68071-4931; 68645-552; 0185-0630; 68071-3043; 67296-1202; 52427-440; 60687-646; 68788-7746; 70518-2561; 65862-038; 43547-352; 15308-0800; 68071-2224; 70518-2600; 52427-443; 70518-2655; 43353-270; 70934-171; 68001-486; 70882-103; 60760-359; 71610-588; 69117-0014; 76282-420; 68084-199; 64679-941; 63629-8736; 71335-1426; 68788-6820; 68180-982; 63187-237; 68180-979; 67651-0225; 55700-547; 54458-872; 65862-037; 0904-7200; 16729-376; 71335-0015; 70934-120; 68645-550; 55154-4992; 72865-212; 51655-335; 65862-040; 43063-800; 0143-9713; 60687-678; 51655-292; 68180-513; 17404-0011; 65730-1301; 76282-421; 71610-536; 16729-379; 68788-6407; 64679-942; 0904-6798; 50436-0354; 70518-1790; 50090-2431; 68788-7334; 43063-815; 43353-301; 60760-455; 31722-172; 43547-414; 60760-380; 31722-176; 71335-0176; 55700-513; 72865-208; 63187-825; 63187-257; 16729-378; 61919-161; 70518-1665; 54458-877; 42708-031; 71335-0354; 68788-6811; 0185-0620; 71335-0536; 43063-786; 31722-180; 63187-780; 63187-099; 60760-358; 55154-2329; 43547-351; 43547-353; 68180-512; 60687-667; 70518-0134; 31722-177; 61919-909; 71205-180; 57297-511; 68645-553; 63629-8823; 50090-3175; 69117-0036; 43063-810; 68788-7633; 68071-5036; 76282-419; 71335-1295; 70934-200; 16729-375; 53002-1463; 50090-0808; 43063-811; 68071-5089; 55154-2131; 43063-769; 76282-422; 42708-032; 63629-5247; 70518-1152; 0185-0602; 71610-406; 70882-104; 71335-1380; 68645-555; 71610-638; 68071-4660; 70518-0117; 50090-4991; 60687-333; 68084-765; 67296-1249; 70518-0544; 70934-155; 60687-656; 68071-5046; 43353-793; 55154-8077; 63827-1012; 68180-980; 43353-662; 55154-8078; 60687-325; 68071-3064; 70518-0468; 68645-554; 16729-377; 50090-3757; 68071-3220; 70934-919; 53002-1225; 68001-335; 60760-390; 52427-438; 68645-587; 43547-416; 43353-271; 43063-812; 60760-438; 67296-1154; 71610-279; 52427-442; 64679-929; 71205-471; 68645-551; 55700-480
Synonyms Lisinopril | Lysinopril | Lisinopril Sulfate (1:2) | Prinivil | Zestril | Lisinopril Maleate (1:1) | MK-521
Chemical Information
Molecular Formula C21H31N3O5
CAS Registry Number 76547-98-3
SMILES C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Blood pressure decreasedAngiotensin-converting enzymeP12821T8257716395257; 16138565; 9270093; 10535720; 9726242; 10620209; 10880412; 8986921; 10999650
CoughB2 bradykinin receptorP30411T2371410904024; 12522467; 11699055; 15894833
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.0040.000073%Not Available
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abnormal weight gain14.03.02.0100.000021%Not Available
Abortion spontaneous18.01.04.001--Not Available
Abscess11.01.08.0010.000031%Not Available
Acidosis14.01.03.0020.000031%
Acidosis hyperchloraemic14.01.01.0070.000063%Not Available
Acute hepatic failure09.01.03.0010.000038%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000019%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000033%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000042%
Ageusia17.02.07.001; 07.14.03.003--Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.0060.001273%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000167%Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.0070.000021%Not Available
Anger19.04.02.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
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