Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lindane
Drug ID BADD_D01294
Description An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment. Lindane is still allowed for pharmaceutical use until 2015.
Indications and Usage For the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies.
Marketing Status Prescription; Discontinued
ATC Code P03AB02
DrugBank ID DB00431
KEGG ID D00360
MeSH ID D001556
PubChem ID 727
TTD Drug ID D0Q5IN
NDC Product Code 60432-834
Synonyms Hexachlorocyclohexane | Hexachlorane | Benzene Hexachloride | Hexachloride, Benzene | Epsilon-hexachlorocyclohexane | Epsilon hexachlorocyclohexane | Zeta-hexachlorocyclohexane | Zeta hexachlorocyclohexane | Lindane | gamma-Benzene Hexachloride | Hexachloride, gamma-Benzene | gamma Benzene Hexachloride | Gamma-666 | Gamma 666 | Gammexane | gamma-HCH | gamma HCH | gamma-Hexachlorocyclohexane | gamma Hexachlorocyclohexane | BHC Insecticide | Insecticide, BHC | PMS-Lindane | PMS Lindane | Kwell | Scabecid | Jacutin | Scabene | Tetocid | Scabisan | Eta-hexachlorocyclohexane | Eta hexachlorocyclohexane | Delitex
Chemical Information
Molecular Formula C6H6Cl6
CAS Registry Number 319-84-6
SMILES C1(C(C(C(C(C1Cl)Cl)Cl)Cl)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Lipid metabolism disordersFatty acid synthaseP49327T165147535533; 7945678; 9031527; 9622850; 8721217; 34677; 1138036; 1979951
Lipid metabolism disordersATP-citrate synthaseP53396T521897535533; 7945678; 9031527; 9622850; 8721217; 34677; 1138036; 1979951
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Headache17.14.01.001--
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Pruritus23.03.12.001--
Seizure17.12.03.001--
Urticaria10.01.06.001; 23.04.02.001--
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