Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Linagliptin
Drug ID BADD_D01292
Description Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [L9557]. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding[A37050]. Linagliptin was approved by the FDA on May 2, 2011[L9557].
Indications and Usage Linagliptin is used for the management of type 2 diabetes mellitus.
Marketing Status Prescription
ATC Code A10BH05
DrugBank ID DB08882
KEGG ID D09566
MeSH ID D000069476
PubChem ID 10096344
TTD Drug ID D02EYG
NDC Product Code 69037-0008; 0597-0140; 53104-7701; 46708-892; 50090-4383; 65862-970; 55111-972; 50370-0045; 65727-057; 62993-0808; 12714-153; 62756-492; 55154-0410; 63415-0521; 66039-908; 65015-854
Synonyms Linagliptin | (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione | 1H-purine-2,6-dione, 8-((3r)-3-amino-1-piperidinyl)-7-(2-butynyl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)- | BI 1356 | 1356, BI | BI1356 | BI-1356 | Tradjenta | Trajenta
Chemical Information
Molecular Formula C25H28N8O2
CAS Registry Number 668270-12-0
SMILES CC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.015047%Not Available
Abdominal distension07.01.04.0010.002687%
Abdominal pain07.01.05.0020.017734%
Abdominal pain upper07.01.05.0030.006986%
Alanine aminotransferase increased13.03.01.0030.002150%
Albuminuria20.02.01.0010.001075%Not Available
Alopecia23.02.02.001--
Amylase increased13.05.01.0090.004299%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angina pectoris02.02.02.002; 24.04.04.0020.001075%
Angioedema23.04.01.001; 10.01.05.0090.003224%Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.0010.011823%
Arthritis15.01.01.0010.001075%
Aspartate aminotransferase increased13.03.01.0060.001612%
Asthenia08.01.01.001--Not Available
Back pain15.03.04.0050.006986%
Blister12.01.06.002; 23.03.01.0010.002687%Not Available
Blood cholesterol increased13.12.01.002--
Blood creatinine increased13.13.01.0040.004299%
Blood glucose abnormal13.02.02.0080.005374%Not Available
Blood glucose decreased13.02.02.0010.002687%Not Available
Blood glucose increased13.02.02.0020.019346%Not Available
Blood pressure decreased13.14.03.0020.001612%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood triglycerides increased13.12.03.0010.001075%Not Available
Blood urea increased13.13.01.0060.001075%Not Available
Blood uric acid increased13.02.04.0010.001612%Not Available
Bone pain15.02.01.001--
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