Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levonorgestrel
Drug ID BADD_D01281
Description Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available.[L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Indications and Usage For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
Marketing Status Prescription; OTC; Discontinued
ATC Code G03AC03; G03AD01
DrugBank ID DB00367
KEGG ID D00950
MeSH ID D016912
PubChem ID 13109
TTD Drug ID D0BA9U
NDC Product Code 50419-424; 73302-911; 22552-0047; 43386-622; 45541-1244; 51660-723; 12866-1010; 50419-422; 63190-0660; 63190-0130; 45541-1174; 65129-2003; 50090-1141; 62756-720; 58602-721; 16714-809; 50419-423; 66499-0018; 69536-162; 69536-146; 40032-622; 71205-361; 57297-852; 0113-2003; 65089-0036; 68071-4247; 58602-712; 0536-1142; 68071-4294; 64122-605; 44132-004; 50090-3830; 68180-853; 69536-200; 51508-012; 69536-103; 58602-841; 59057-002; 53104-7669; 62756-718; 62756-723; 69953-515; 68180-852; 70700-164; 69536-133; 71205-120; 59057-001; 50102-211; 0023-5858; 69953-616; 63190-0850; 68071-4126; 44132-012
Synonyms Levonorgestrel | l-Norgestrel | l Norgestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)- | D-Norgestrel | D Norgestrel | Microval | duofem | Microlut | Mirena | Norgeston | Norplant-2 | Norplant 2 | Norplant2 | NorLevo | Norplant | Plan B | Vikela | Cerazet | Capronor
Chemical Information
Molecular Formula C21H28O2
CAS Registry Number 797-63-7
SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Uterine stenosis21.07.01.0210.002085%Not Available
Vaginal perforation21.08.01.016; 12.02.14.0090.002085%
Abortion of ectopic pregnancy18.01.01.0050.016676%Not Available
Fear of death19.06.03.0060.007296%Not Available
Allergy to metals10.01.03.0420.007296%Not Available
Amniorrhoea18.05.01.0050.004169%Not Available
Procedural dizziness17.02.05.062; 12.02.04.0120.026056%Not Available
Uterine fibrosis21.07.01.0170.008338%Not Available
Quality of life decreased13.18.01.0130.011465%Not Available
Uterine cervix stenosis21.06.01.0150.112564%Not Available
Penis injury12.01.15.006; 21.12.01.0210.004169%Not Available
Cervix inflammation21.14.05.0030.007296%Not Available
Actinomyces test positive13.08.01.0050.023972%Not Available
Streptococcus test positive13.08.01.0160.002085%Not Available
Chlamydia test positive13.08.01.0060.005211%Not Available
Oestrogen receptor positive breast cancer21.05.01.025; 16.10.01.0160.007296%Not Available
Subchorionic haemorrhage24.07.03.030; 18.02.01.0070.005211%Not Available
Seizure like phenomena17.12.03.0300.002085%Not Available
Human chorionic gonadotropin abnormal13.10.05.0220.002085%Not Available
Human chorionic gonadotropin decreased13.10.05.0230.007296%Not Available
Human chorionic gonadotropin increased13.10.05.024--Not Available
Seizure cluster17.12.03.0290.002085%Not Available
Psychological trauma19.01.02.0170.038563%Not Available
Vertebral artery dissection24.02.04.006; 17.08.06.0040.002085%Not Available
Spinal pain08.01.08.030; 17.10.01.020; 15.02.01.0080.006254%Not Available
Ovarian vein thrombosis24.01.05.012; 21.11.02.0190.005211%Not Available
Sirenomelia15.11.07.027; 03.11.07.027; 20.08.03.0060.000544%Not Available
Pelvic cyst21.07.04.010; 16.04.01.0050.003127%Not Available
Preterm premature rupture of membranes18.02.02.0160.005211%Not Available
Invasive ductal breast carcinoma21.05.01.021; 16.10.01.0130.035437%Not Available
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