Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levonorgestrel
Drug ID BADD_D01281
Description Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available.[L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Indications and Usage For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
Marketing Status Prescription; OTC; Discontinued
ATC Code G03AC03; G03AD01
DrugBank ID DB00367
KEGG ID D00950
MeSH ID D016912
PubChem ID 13109
TTD Drug ID D0BA9U
NDC Product Code 50419-424; 73302-911; 22552-0047; 43386-622; 45541-1244; 51660-723; 12866-1010; 50419-422; 63190-0660; 63190-0130; 45541-1174; 65129-2003; 50090-1141; 62756-720; 58602-721; 16714-809; 50419-423; 66499-0018; 69536-162; 69536-146; 40032-622; 71205-361; 57297-852; 0113-2003; 65089-0036; 68071-4247; 58602-712; 0536-1142; 68071-4294; 64122-605; 44132-004; 50090-3830; 68180-853; 69536-200; 51508-012; 69536-103; 58602-841; 59057-002; 53104-7669; 62756-718; 62756-723; 69953-515; 68180-852; 70700-164; 69536-133; 71205-120; 59057-001; 50102-211; 0023-5858; 69953-616; 63190-0850; 68071-4126; 44132-012
Synonyms Levonorgestrel | l-Norgestrel | l Norgestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)- | D-Norgestrel | D Norgestrel | Microval | duofem | Microlut | Mirena | Norgeston | Norplant-2 | Norplant 2 | Norplant2 | NorLevo | Norplant | Plan B | Vikela | Cerazet | Capronor
Chemical Information
Molecular Formula C21H28O2
CAS Registry Number 797-63-7
SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intestinal perforation07.04.06.002--Not Available
Intracranial aneurysm24.02.04.001; 17.08.06.0010.003127%Not Available
Intracranial pressure increased17.07.02.0020.651410%Not Available
Intraocular pressure increased13.07.04.002--Not Available
Iron deficiency anaemia01.03.01.002; 14.13.02.001--Not Available
Irritability19.04.02.013; 08.01.03.0110.177183%
Irritable bowel syndrome19.24.01.003; 07.02.04.003--Not Available
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.004--Not Available
Joint dislocation15.01.07.002; 12.04.02.007--Not Available
Joint effusion15.01.02.005--
Joint swelling15.01.02.004--Not Available
Keloid scar23.01.03.0020.002085%Not Available
Kidney infection20.01.09.004; 11.01.14.006--
Labyrinthitis11.01.05.002; 04.04.03.0010.002085%Not Available
Lacrimation increased06.08.02.004--
Large intestine perforation12.02.03.005; 07.04.06.0050.001631%
Leiomyoma15.09.02.002; 16.18.01.0030.003127%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.0010.127155%
Libido increased21.03.02.007; 19.08.03.0020.003127%
Limb malformation15.11.07.006; 03.11.07.0060.002085%Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.005--Not Available
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Loss of libido19.08.03.0030.305381%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
Lung disorder22.02.07.001--Not Available
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