Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levomilnacipran hydrochloride
Drug ID BADD_D01280
Description Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor. Chemically, levomilnacipran is the 1S,2R-enantiomer of milnacipran. FDA approved on July 25, 2013.
Indications and Usage Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor and is indicated for the treatment of major depressive disorder (MDD).
Marketing Status Prescription; Discontinued
ATC Code N06AX28
DrugBank ID DB08918
KEGG ID D10133
MeSH ID D000078862
PubChem ID 6917778
TTD Drug ID D02XOK
NDC Product Code 50370-0043; 0456-2213; 0456-2280; 0456-2212; 0456-2281; 69766-018; 0456-2241; 0456-2221; 0456-2202; 51604-1183; 53069-1090; 53069-1100; 0456-2240; 0456-2220
Synonyms Levomilnacipran | Fetzima | Levomilnacipran Hydrochloride
Chemical Information
Molecular Formula C15H23ClN2O
CAS Registry Number 101152-94-7
SMILES CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.010--
Skin disorder23.03.03.007--Not Available
Suicidal ideation19.12.01.003--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tension19.06.02.005--Not Available
Testicular pain21.13.01.005--
Thirst08.01.09.021; 14.03.02.007--Not Available
Urethral disorder20.07.01.002--Not Available
Urinary hesitation20.02.02.009--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Ventricular extrasystoles02.03.04.007--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Yawning22.02.05.017--Not Available
Labile hypertension24.08.02.013--Not Available
Organic erectile dysfunction21.03.01.013; 19.08.04.006--Not Available
Psychogenic erectile dysfunction19.08.04.007; 21.03.01.015--Not Available
Protein urine present13.13.02.006--Not Available
Blood pressure orthostatic increased13.14.03.024--Not Available
Angiopathy24.03.02.007--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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